hERG1 channel subunit composition mediates proton inhibition of rapid delayed rectifier potassium current (I(Kr)) in cardiomyocytes derived from hiPSCs

The voltage-gated channel, hERG1, conducts the rapid delayed rectifier potassium current (I(Kr)) and is critical for human cardiac repolarization. Reduced I(Kr) causes long QT syndrome and increases the risk for cardiac arrhythmia and sudden death. At least two subunits form functional hERG1 channel...

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Detalles Bibliográficos
Autores principales: Ukachukwu, Chiamaka U., Jimenez-Vazquez, Eric N., Jain, Abhilasha, Jones, David K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9867984/
https://www.ncbi.nlm.nih.gov/pubmed/36496073
http://dx.doi.org/10.1016/j.jbc.2022.102778

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