Lyophilized mRNA-lipid nanoparticle vaccines with long-term stability and high antigenicity against SARS-CoV-2

Advanced mRNA vaccines play vital roles against SARS-CoV-2. However, most current mRNA delivery platforms need to be stored at −20 °C or −70 °C due to their poor stability, which severely restricts their availability. Herein, we develop a lyophilization technique to prepare SARS-CoV-2 mRNA-lipid nan...

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Detalles Bibliográficos
Autores principales: Ai, Liangxia, Li, Yafei, Zhou, Li, Yao, Wenrong, Zhang, Hao, Hu, Zhaoyu, Han, Jinyu, Wang, Weijie, Wu, Junmiao, Xu, Pan, Wang, Ruiyue, Li, Zhangyi, Li, Zhouwang, Wei, Chengliang, Liang, Jianqun, Chen, Haobo, Yang, Zhimiao, Guo, Ming, Huang, Zhixiang, Wang, Xin, Zhang, Zhen, Xiang, Wenjie, Sun, Dazheng, Xu, Lianqiang, Huang, Meiyan, Lv, Bin, Peng, Peiqi, Zhang, Shangfeng, Ji, Xuhao, Luo, Huiyi, Chen, Nanping, Chen, Jianping, Lan, Ke, Hu, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9868121/
https://www.ncbi.nlm.nih.gov/pubmed/36683074
http://dx.doi.org/10.1038/s41421-022-00517-9

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