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Central Mechanism of Acupuncture Treatment in Patients with Migraine: Study Protocol for Randomized Controlled Neuroimaging Trial

PURPOSE: Acupuncture has been recognized as an effective and safe alternative therapy for migraine, but its central mechanism has not yet been adequately explained. Meanwhile, research into the clinical efficacy and central mechanism of true acupuncture (TA) and sham acupuncture (SA) is lacking. It...

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Autores principales: Jia, Jingnan, Yan, Chaoqun, Zheng, Xiancheng, Shi, Anqi, Li, Zhijun, Xu, Lufan, Hui, Zhiyuan, Chen, Yichao, Cao, Zimin, Wang, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9868142/
https://www.ncbi.nlm.nih.gov/pubmed/36700155
http://dx.doi.org/10.2147/JPR.S377289
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author Jia, Jingnan
Yan, Chaoqun
Zheng, Xiancheng
Shi, Anqi
Li, Zhijun
Xu, Lufan
Hui, Zhiyuan
Chen, Yichao
Cao, Zimin
Wang, Jun
author_facet Jia, Jingnan
Yan, Chaoqun
Zheng, Xiancheng
Shi, Anqi
Li, Zhijun
Xu, Lufan
Hui, Zhiyuan
Chen, Yichao
Cao, Zimin
Wang, Jun
author_sort Jia, Jingnan
collection PubMed
description PURPOSE: Acupuncture has been recognized as an effective and safe alternative therapy for migraine, but its central mechanism has not yet been adequately explained. Meanwhile, research into the clinical efficacy and central mechanism of true acupuncture (TA) and sham acupuncture (SA) is lacking. It is necessary to investigate whether TA has better efficacy than SA, and how they achieve different effects. This study aims to evaluate the efficacy of TA and SA, observe the brain response caused by TA and SA, and further investigate the central nervous mechanism of TA and SA treatment for patients with migraine. PATIENTS AND METHODS: This is a randomized controlled neuroimaging trial combining acupuncture treatment with functional magnetic resonance imaging, with patients and outcome assessors blinded. A total of 60 patients with migraine will be randomly allocated to receive 12 sessions of either TA or SA treatments (three sessions per week for 4 weeks), and 30 healthy participants will be recruited as the healthy control (HC) group. Outcome assessment and neuroimaging will be conducted before and after the entire intervention. A headache diary and questionnaires of life quality and psychological properties will be used to evaluate clinical efficacy. Multimodal magnetic resonance imagining data analysis will be used to investigate the central mechanism of TA or SA in treating migraine. Pearson’s correlation analysis will be used to reveal the relationship between the brain response and clinical improvements. CONCLUSION: The results of this study will reveal the brain response to TA and SA in patients with migraine and contribute to further expanding the knowledge of their central mechanism. STUDY REGISTRATION: This trial has been approved by the ethics committee of Dongzhimen Hospital affiliated to Beijing University of Chinese Medicine (DZMEC-KY-2020-38) and registered in the Chinese Clinical Trial Registry (registration number ChiCTR2000033995).
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spelling pubmed-98681422023-01-24 Central Mechanism of Acupuncture Treatment in Patients with Migraine: Study Protocol for Randomized Controlled Neuroimaging Trial Jia, Jingnan Yan, Chaoqun Zheng, Xiancheng Shi, Anqi Li, Zhijun Xu, Lufan Hui, Zhiyuan Chen, Yichao Cao, Zimin Wang, Jun J Pain Res Study Protocol PURPOSE: Acupuncture has been recognized as an effective and safe alternative therapy for migraine, but its central mechanism has not yet been adequately explained. Meanwhile, research into the clinical efficacy and central mechanism of true acupuncture (TA) and sham acupuncture (SA) is lacking. It is necessary to investigate whether TA has better efficacy than SA, and how they achieve different effects. This study aims to evaluate the efficacy of TA and SA, observe the brain response caused by TA and SA, and further investigate the central nervous mechanism of TA and SA treatment for patients with migraine. PATIENTS AND METHODS: This is a randomized controlled neuroimaging trial combining acupuncture treatment with functional magnetic resonance imaging, with patients and outcome assessors blinded. A total of 60 patients with migraine will be randomly allocated to receive 12 sessions of either TA or SA treatments (three sessions per week for 4 weeks), and 30 healthy participants will be recruited as the healthy control (HC) group. Outcome assessment and neuroimaging will be conducted before and after the entire intervention. A headache diary and questionnaires of life quality and psychological properties will be used to evaluate clinical efficacy. Multimodal magnetic resonance imagining data analysis will be used to investigate the central mechanism of TA or SA in treating migraine. Pearson’s correlation analysis will be used to reveal the relationship between the brain response and clinical improvements. CONCLUSION: The results of this study will reveal the brain response to TA and SA in patients with migraine and contribute to further expanding the knowledge of their central mechanism. STUDY REGISTRATION: This trial has been approved by the ethics committee of Dongzhimen Hospital affiliated to Beijing University of Chinese Medicine (DZMEC-KY-2020-38) and registered in the Chinese Clinical Trial Registry (registration number ChiCTR2000033995). Dove 2023-01-18 /pmc/articles/PMC9868142/ /pubmed/36700155 http://dx.doi.org/10.2147/JPR.S377289 Text en © 2023 Jia et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Study Protocol
Jia, Jingnan
Yan, Chaoqun
Zheng, Xiancheng
Shi, Anqi
Li, Zhijun
Xu, Lufan
Hui, Zhiyuan
Chen, Yichao
Cao, Zimin
Wang, Jun
Central Mechanism of Acupuncture Treatment in Patients with Migraine: Study Protocol for Randomized Controlled Neuroimaging Trial
title Central Mechanism of Acupuncture Treatment in Patients with Migraine: Study Protocol for Randomized Controlled Neuroimaging Trial
title_full Central Mechanism of Acupuncture Treatment in Patients with Migraine: Study Protocol for Randomized Controlled Neuroimaging Trial
title_fullStr Central Mechanism of Acupuncture Treatment in Patients with Migraine: Study Protocol for Randomized Controlled Neuroimaging Trial
title_full_unstemmed Central Mechanism of Acupuncture Treatment in Patients with Migraine: Study Protocol for Randomized Controlled Neuroimaging Trial
title_short Central Mechanism of Acupuncture Treatment in Patients with Migraine: Study Protocol for Randomized Controlled Neuroimaging Trial
title_sort central mechanism of acupuncture treatment in patients with migraine: study protocol for randomized controlled neuroimaging trial
topic Study Protocol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9868142/
https://www.ncbi.nlm.nih.gov/pubmed/36700155
http://dx.doi.org/10.2147/JPR.S377289
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