Epigenetic modifications in chronic rhinosinusitis with and without nasal polyps

Chronic rhinosinusitis (CRS) has brought a huge socioeconomic burden. However, its mechanism is still elusive, which may involve genetic, environmental and some other factors. Epigenetic analyses have been conducted to explore the mechanisms underlying CRS. Here, we reviewed the fruits in the epigen...

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Autores principales: Li, Jing, Qiu, Chang-Yu, Tao, Yue-Jin, Cheng, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9868256/
https://www.ncbi.nlm.nih.gov/pubmed/36699454
http://dx.doi.org/10.3389/fgene.2022.1089647
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author Li, Jing
Qiu, Chang-Yu
Tao, Yue-Jin
Cheng, Lei
author_facet Li, Jing
Qiu, Chang-Yu
Tao, Yue-Jin
Cheng, Lei
author_sort Li, Jing
collection PubMed
description Chronic rhinosinusitis (CRS) has brought a huge socioeconomic burden. However, its mechanism is still elusive, which may involve genetic, environmental and some other factors. Epigenetic analyses have been conducted to explore the mechanisms underlying CRS. Here, we reviewed the fruits in the epigenetic studies on DNA methylation, histone modification, and non-coding RNA regulation. We concluded that the epigenetic research on CRS has made great breakthroughs, especially in the past 5 years and the field of microRNAs. “Epigenetic therapies” are expected to be designed to treat CRS in the future.
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spelling pubmed-98682562023-01-24 Epigenetic modifications in chronic rhinosinusitis with and without nasal polyps Li, Jing Qiu, Chang-Yu Tao, Yue-Jin Cheng, Lei Front Genet Genetics Chronic rhinosinusitis (CRS) has brought a huge socioeconomic burden. However, its mechanism is still elusive, which may involve genetic, environmental and some other factors. Epigenetic analyses have been conducted to explore the mechanisms underlying CRS. Here, we reviewed the fruits in the epigenetic studies on DNA methylation, histone modification, and non-coding RNA regulation. We concluded that the epigenetic research on CRS has made great breakthroughs, especially in the past 5 years and the field of microRNAs. “Epigenetic therapies” are expected to be designed to treat CRS in the future. Frontiers Media S.A. 2023-01-09 /pmc/articles/PMC9868256/ /pubmed/36699454 http://dx.doi.org/10.3389/fgene.2022.1089647 Text en Copyright © 2023 Li, Qiu, Tao and Cheng. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Li, Jing
Qiu, Chang-Yu
Tao, Yue-Jin
Cheng, Lei
Epigenetic modifications in chronic rhinosinusitis with and without nasal polyps
title Epigenetic modifications in chronic rhinosinusitis with and without nasal polyps
title_full Epigenetic modifications in chronic rhinosinusitis with and without nasal polyps
title_fullStr Epigenetic modifications in chronic rhinosinusitis with and without nasal polyps
title_full_unstemmed Epigenetic modifications in chronic rhinosinusitis with and without nasal polyps
title_short Epigenetic modifications in chronic rhinosinusitis with and without nasal polyps
title_sort epigenetic modifications in chronic rhinosinusitis with and without nasal polyps
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9868256/
https://www.ncbi.nlm.nih.gov/pubmed/36699454
http://dx.doi.org/10.3389/fgene.2022.1089647
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