Case report: Sotrovimab, remdesivir and nirmatrelvir/ritonavir combination as salvage treatment option in two immunocompromised patients hospitalized for COVID-19

COVID-19 in immunocompromised patients is difficult to treat. SARS-CoV-2 interaction with the host immune system and the role of therapy still remains only partly understood. There are no data regarding the use of monoclonal antibodies and the combination of two antivirals in fighting viral replicat...

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Autores principales: Baldi, Federico, Dentone, Chiara, Mikulska, Malgorzata, Fenoglio, Daniela, Mirabella, Michele, Magnè, Federica, Portunato, Federica, Altosole, Tiziana, Sepulcri, Chiara, Giacobbe, Daniele Roberto, Uras, Chiara, Scavone, Graziana, Taramasso, Lucia, Orsi, Andrea, Cittadini, Giuseppe, Filaci, Gilberto, Bassetti, Matteo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9868302/
https://www.ncbi.nlm.nih.gov/pubmed/36698815
http://dx.doi.org/10.3389/fmed.2022.1062450
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author Baldi, Federico
Dentone, Chiara
Mikulska, Malgorzata
Fenoglio, Daniela
Mirabella, Michele
Magnè, Federica
Portunato, Federica
Altosole, Tiziana
Sepulcri, Chiara
Giacobbe, Daniele Roberto
Uras, Chiara
Scavone, Graziana
Taramasso, Lucia
Orsi, Andrea
Cittadini, Giuseppe
Filaci, Gilberto
Bassetti, Matteo
author_facet Baldi, Federico
Dentone, Chiara
Mikulska, Malgorzata
Fenoglio, Daniela
Mirabella, Michele
Magnè, Federica
Portunato, Federica
Altosole, Tiziana
Sepulcri, Chiara
Giacobbe, Daniele Roberto
Uras, Chiara
Scavone, Graziana
Taramasso, Lucia
Orsi, Andrea
Cittadini, Giuseppe
Filaci, Gilberto
Bassetti, Matteo
author_sort Baldi, Federico
collection PubMed
description COVID-19 in immunocompromised patients is difficult to treat. SARS-CoV-2 interaction with the host immune system and the role of therapy still remains only partly understood. There are no data regarding the use of monoclonal antibodies and the combination of two antivirals in fighting viral replication and disease progression. We report the cases of two patients, both treated with rituximab for non-Hodgkin lymphoma and granulomatosis with polyangiitis, respectively, and both hospitalized for COVID-19 with positive SARS-CoV-2 RNAemia, who were successfully treated with a salvage combination therapy with sotrovimab, remdesivir and nirmatrelvir/ritonavir.
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spelling pubmed-98683022023-01-24 Case report: Sotrovimab, remdesivir and nirmatrelvir/ritonavir combination as salvage treatment option in two immunocompromised patients hospitalized for COVID-19 Baldi, Federico Dentone, Chiara Mikulska, Malgorzata Fenoglio, Daniela Mirabella, Michele Magnè, Federica Portunato, Federica Altosole, Tiziana Sepulcri, Chiara Giacobbe, Daniele Roberto Uras, Chiara Scavone, Graziana Taramasso, Lucia Orsi, Andrea Cittadini, Giuseppe Filaci, Gilberto Bassetti, Matteo Front Med (Lausanne) Medicine COVID-19 in immunocompromised patients is difficult to treat. SARS-CoV-2 interaction with the host immune system and the role of therapy still remains only partly understood. There are no data regarding the use of monoclonal antibodies and the combination of two antivirals in fighting viral replication and disease progression. We report the cases of two patients, both treated with rituximab for non-Hodgkin lymphoma and granulomatosis with polyangiitis, respectively, and both hospitalized for COVID-19 with positive SARS-CoV-2 RNAemia, who were successfully treated with a salvage combination therapy with sotrovimab, remdesivir and nirmatrelvir/ritonavir. Frontiers Media S.A. 2023-01-09 /pmc/articles/PMC9868302/ /pubmed/36698815 http://dx.doi.org/10.3389/fmed.2022.1062450 Text en Copyright © 2023 Baldi, Dentone, Mikulska, Fenoglio, Mirabella, Magnè, Portunato, Altosole, Sepulcri, Giacobbe, Uras, Scavone, Taramasso, Orsi, Cittadini, Filaci and Bassetti. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Baldi, Federico
Dentone, Chiara
Mikulska, Malgorzata
Fenoglio, Daniela
Mirabella, Michele
Magnè, Federica
Portunato, Federica
Altosole, Tiziana
Sepulcri, Chiara
Giacobbe, Daniele Roberto
Uras, Chiara
Scavone, Graziana
Taramasso, Lucia
Orsi, Andrea
Cittadini, Giuseppe
Filaci, Gilberto
Bassetti, Matteo
Case report: Sotrovimab, remdesivir and nirmatrelvir/ritonavir combination as salvage treatment option in two immunocompromised patients hospitalized for COVID-19
title Case report: Sotrovimab, remdesivir and nirmatrelvir/ritonavir combination as salvage treatment option in two immunocompromised patients hospitalized for COVID-19
title_full Case report: Sotrovimab, remdesivir and nirmatrelvir/ritonavir combination as salvage treatment option in two immunocompromised patients hospitalized for COVID-19
title_fullStr Case report: Sotrovimab, remdesivir and nirmatrelvir/ritonavir combination as salvage treatment option in two immunocompromised patients hospitalized for COVID-19
title_full_unstemmed Case report: Sotrovimab, remdesivir and nirmatrelvir/ritonavir combination as salvage treatment option in two immunocompromised patients hospitalized for COVID-19
title_short Case report: Sotrovimab, remdesivir and nirmatrelvir/ritonavir combination as salvage treatment option in two immunocompromised patients hospitalized for COVID-19
title_sort case report: sotrovimab, remdesivir and nirmatrelvir/ritonavir combination as salvage treatment option in two immunocompromised patients hospitalized for covid-19
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9868302/
https://www.ncbi.nlm.nih.gov/pubmed/36698815
http://dx.doi.org/10.3389/fmed.2022.1062450
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