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Research progress of treatment of functional dyspepsia with traditional Chinese medicine compound based on cell signal pathway

Functional dyspepsia (FD) is the most common clinical gastrointestinal disease, with complex and prolonged clinical symptoms. The prevalence of FD is increasing year by year, seriously affecting the quality of life of patients. The main causes of FD are related to abnormal gastrointestinal dynamics,...

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Autores principales: Song, Yujiao, Yin, Defei, Zhang, Zhenyi, Chi, Lili
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9868459/
https://www.ncbi.nlm.nih.gov/pubmed/36699059
http://dx.doi.org/10.3389/fphar.2022.1089231
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author Song, Yujiao
Yin, Defei
Zhang, Zhenyi
Chi, Lili
author_facet Song, Yujiao
Yin, Defei
Zhang, Zhenyi
Chi, Lili
author_sort Song, Yujiao
collection PubMed
description Functional dyspepsia (FD) is the most common clinical gastrointestinal disease, with complex and prolonged clinical symptoms. The prevalence of FD is increasing year by year, seriously affecting the quality of life of patients. The main causes of FD are related to abnormal gastrointestinal dynamics, increased visceral sensitivity, Helicobacter pylori (HP) infection, intestinal flora disturbance and psychological factors. A review of the relevant literature reveals that the mechanisms of traditional Chinese medicine (TCM) in the treatment of FD mainly involve the following pathways:5-HT signal pathway, AMPK signal pathway,C-kit signal pathway, CRF signal pathway, PERK signal pathway,NF-κB signal pathway. Based on a holistic concept, TCM promotes gastrointestinal motility, regulates visceral sensitivity and alleviates gastrointestinal inflammation through multiple signal pathways, reflecting the advantages of multi-level, multi-pathway and multi-targeted treatment of FD.
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spelling pubmed-98684592023-01-24 Research progress of treatment of functional dyspepsia with traditional Chinese medicine compound based on cell signal pathway Song, Yujiao Yin, Defei Zhang, Zhenyi Chi, Lili Front Pharmacol Pharmacology Functional dyspepsia (FD) is the most common clinical gastrointestinal disease, with complex and prolonged clinical symptoms. The prevalence of FD is increasing year by year, seriously affecting the quality of life of patients. The main causes of FD are related to abnormal gastrointestinal dynamics, increased visceral sensitivity, Helicobacter pylori (HP) infection, intestinal flora disturbance and psychological factors. A review of the relevant literature reveals that the mechanisms of traditional Chinese medicine (TCM) in the treatment of FD mainly involve the following pathways:5-HT signal pathway, AMPK signal pathway,C-kit signal pathway, CRF signal pathway, PERK signal pathway,NF-κB signal pathway. Based on a holistic concept, TCM promotes gastrointestinal motility, regulates visceral sensitivity and alleviates gastrointestinal inflammation through multiple signal pathways, reflecting the advantages of multi-level, multi-pathway and multi-targeted treatment of FD. Frontiers Media S.A. 2023-01-09 /pmc/articles/PMC9868459/ /pubmed/36699059 http://dx.doi.org/10.3389/fphar.2022.1089231 Text en Copyright © 2023 Song, Yin, Zhang and Chi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Song, Yujiao
Yin, Defei
Zhang, Zhenyi
Chi, Lili
Research progress of treatment of functional dyspepsia with traditional Chinese medicine compound based on cell signal pathway
title Research progress of treatment of functional dyspepsia with traditional Chinese medicine compound based on cell signal pathway
title_full Research progress of treatment of functional dyspepsia with traditional Chinese medicine compound based on cell signal pathway
title_fullStr Research progress of treatment of functional dyspepsia with traditional Chinese medicine compound based on cell signal pathway
title_full_unstemmed Research progress of treatment of functional dyspepsia with traditional Chinese medicine compound based on cell signal pathway
title_short Research progress of treatment of functional dyspepsia with traditional Chinese medicine compound based on cell signal pathway
title_sort research progress of treatment of functional dyspepsia with traditional chinese medicine compound based on cell signal pathway
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9868459/
https://www.ncbi.nlm.nih.gov/pubmed/36699059
http://dx.doi.org/10.3389/fphar.2022.1089231
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