Fibroblast growth factor-21 (FGF21) analogs as possible treatment options for diabetes mellitus in veterinary patients

Fibroblast growth factors (FGFs) are involved in numerous metabolic processes. The endocrine subfamily of FGFs, consisting of FGF19, FGF21, and FGF23, might have beneficial effects in the treatment of diabetes mellitus (DM) and/or obesity. The analog with the greatest potential, FGF21, lowers blood...

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Autores principales: Corbee, Ronald J., van Everdingen, Dion L., Kooistra, Hans S., Penning, Louis C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Veterinary Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9868460/
https://www.ncbi.nlm.nih.gov/pubmed/36699319
http://dx.doi.org/10.3389/fvets.2022.1086987
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author Corbee, Ronald J.
van Everdingen, Dion L.
Kooistra, Hans S.
Penning, Louis C.
author_facet Corbee, Ronald J.
van Everdingen, Dion L.
Kooistra, Hans S.
Penning, Louis C.
author_sort Corbee, Ronald J.
collection PubMed
description Fibroblast growth factors (FGFs) are involved in numerous metabolic processes. The endocrine subfamily of FGFs, consisting of FGF19, FGF21, and FGF23, might have beneficial effects in the treatment of diabetes mellitus (DM) and/or obesity. The analog with the greatest potential, FGF21, lowers blood glucose levels, improves insulin sensitivity, and induces weight loss in several animal models. In this review we summarize recent (pre)clinical findings with FGF21 analogs in animal models and men. Furthermore, possible applications of FGF21 analogs for pets with DM will be discussed. As currently, information about the use of FGF21 analogs in pet animals is scarce.
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spelling pubmed-98684602023-01-24 Fibroblast growth factor-21 (FGF21) analogs as possible treatment options for diabetes mellitus in veterinary patients Corbee, Ronald J. van Everdingen, Dion L. Kooistra, Hans S. Penning, Louis C. Front Vet Sci Veterinary Science Fibroblast growth factors (FGFs) are involved in numerous metabolic processes. The endocrine subfamily of FGFs, consisting of FGF19, FGF21, and FGF23, might have beneficial effects in the treatment of diabetes mellitus (DM) and/or obesity. The analog with the greatest potential, FGF21, lowers blood glucose levels, improves insulin sensitivity, and induces weight loss in several animal models. In this review we summarize recent (pre)clinical findings with FGF21 analogs in animal models and men. Furthermore, possible applications of FGF21 analogs for pets with DM will be discussed. As currently, information about the use of FGF21 analogs in pet animals is scarce. Frontiers Media S.A. 2023-01-09 /pmc/articles/PMC9868460/ /pubmed/36699319 http://dx.doi.org/10.3389/fvets.2022.1086987 Text en Copyright © 2023 Corbee, van Everdingen, Kooistra and Penning. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
Corbee, Ronald J.
van Everdingen, Dion L.
Kooistra, Hans S.
Penning, Louis C.
Fibroblast growth factor-21 (FGF21) analogs as possible treatment options for diabetes mellitus in veterinary patients
title Fibroblast growth factor-21 (FGF21) analogs as possible treatment options for diabetes mellitus in veterinary patients
title_full Fibroblast growth factor-21 (FGF21) analogs as possible treatment options for diabetes mellitus in veterinary patients
title_fullStr Fibroblast growth factor-21 (FGF21) analogs as possible treatment options for diabetes mellitus in veterinary patients
title_full_unstemmed Fibroblast growth factor-21 (FGF21) analogs as possible treatment options for diabetes mellitus in veterinary patients
title_short Fibroblast growth factor-21 (FGF21) analogs as possible treatment options for diabetes mellitus in veterinary patients
title_sort fibroblast growth factor-21 (fgf21) analogs as possible treatment options for diabetes mellitus in veterinary patients
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9868460/
https://www.ncbi.nlm.nih.gov/pubmed/36699319
http://dx.doi.org/10.3389/fvets.2022.1086987
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