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Case report: Kimura's disease with minimal degenerative glomerulopathy without eosinophil infiltration responds to mycophenolate mofetil treatment

Kimura's disease (KD) is a rare chronic progressive immune inflammatory disease. The etiology is unknown and manifests as a chronic inflammatory process, which is more common in young Asian men. The clinical manifestations are painless subcutaneous swelling of the head and neck and periauricula...

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Autores principales: Han, Qing, Han, Jie, Wang, Weitao, Gao, Jie, Qiao, Youzhen, Jia, Junfeng, Zhang, Kui, Zheng, Zhaohui, Zhu, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9868591/
https://www.ncbi.nlm.nih.gov/pubmed/36698834
http://dx.doi.org/10.3389/fmed.2022.1069553
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author Han, Qing
Han, Jie
Wang, Weitao
Gao, Jie
Qiao, Youzhen
Jia, Junfeng
Zhang, Kui
Zheng, Zhaohui
Zhu, Ping
author_facet Han, Qing
Han, Jie
Wang, Weitao
Gao, Jie
Qiao, Youzhen
Jia, Junfeng
Zhang, Kui
Zheng, Zhaohui
Zhu, Ping
author_sort Han, Qing
collection PubMed
description Kimura's disease (KD) is a rare chronic progressive immune inflammatory disease. The etiology is unknown and manifests as a chronic inflammatory process, which is more common in young Asian men. The clinical manifestations are painless subcutaneous swelling of the head and neck and periauricular lymphadenopathy, which is slow growing and has a benign course. KD may involve the kidney, and pathological examination revealed eosinophil infiltration in the renal tissue. Proteinuria has been reported in 12–16% of KD cases, and about 60–70% of KD patients will develop nephrotic proteinuria. KD is easily confused with nephrotic syndrome, because KD does not have specific clinical manifestations, laboratory and imaging, and early misdiagnosis is easy. We report a case of KD that was biopsy-proven to have minimal lesion glomerulopathy after ~11 years. In this report, we describe a clinical case of KD with nephrotic syndrome, but there's no eosinophil infiltration in the kidneys. The clinical manifestations of KD recurrence were bilateral eyelid edema, bilateral lower limb swelling, and massive proteinuria in response to mycophenolate mofetil treatment (1.5 g).
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spelling pubmed-98685912023-01-24 Case report: Kimura's disease with minimal degenerative glomerulopathy without eosinophil infiltration responds to mycophenolate mofetil treatment Han, Qing Han, Jie Wang, Weitao Gao, Jie Qiao, Youzhen Jia, Junfeng Zhang, Kui Zheng, Zhaohui Zhu, Ping Front Med (Lausanne) Medicine Kimura's disease (KD) is a rare chronic progressive immune inflammatory disease. The etiology is unknown and manifests as a chronic inflammatory process, which is more common in young Asian men. The clinical manifestations are painless subcutaneous swelling of the head and neck and periauricular lymphadenopathy, which is slow growing and has a benign course. KD may involve the kidney, and pathological examination revealed eosinophil infiltration in the renal tissue. Proteinuria has been reported in 12–16% of KD cases, and about 60–70% of KD patients will develop nephrotic proteinuria. KD is easily confused with nephrotic syndrome, because KD does not have specific clinical manifestations, laboratory and imaging, and early misdiagnosis is easy. We report a case of KD that was biopsy-proven to have minimal lesion glomerulopathy after ~11 years. In this report, we describe a clinical case of KD with nephrotic syndrome, but there's no eosinophil infiltration in the kidneys. The clinical manifestations of KD recurrence were bilateral eyelid edema, bilateral lower limb swelling, and massive proteinuria in response to mycophenolate mofetil treatment (1.5 g). Frontiers Media S.A. 2023-01-09 /pmc/articles/PMC9868591/ /pubmed/36698834 http://dx.doi.org/10.3389/fmed.2022.1069553 Text en Copyright © 2023 Han, Han, Wang, Gao, Qiao, Jia, Zhang, Zheng and Zhu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Han, Qing
Han, Jie
Wang, Weitao
Gao, Jie
Qiao, Youzhen
Jia, Junfeng
Zhang, Kui
Zheng, Zhaohui
Zhu, Ping
Case report: Kimura's disease with minimal degenerative glomerulopathy without eosinophil infiltration responds to mycophenolate mofetil treatment
title Case report: Kimura's disease with minimal degenerative glomerulopathy without eosinophil infiltration responds to mycophenolate mofetil treatment
title_full Case report: Kimura's disease with minimal degenerative glomerulopathy without eosinophil infiltration responds to mycophenolate mofetil treatment
title_fullStr Case report: Kimura's disease with minimal degenerative glomerulopathy without eosinophil infiltration responds to mycophenolate mofetil treatment
title_full_unstemmed Case report: Kimura's disease with minimal degenerative glomerulopathy without eosinophil infiltration responds to mycophenolate mofetil treatment
title_short Case report: Kimura's disease with minimal degenerative glomerulopathy without eosinophil infiltration responds to mycophenolate mofetil treatment
title_sort case report: kimura's disease with minimal degenerative glomerulopathy without eosinophil infiltration responds to mycophenolate mofetil treatment
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9868591/
https://www.ncbi.nlm.nih.gov/pubmed/36698834
http://dx.doi.org/10.3389/fmed.2022.1069553
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