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The association between chronic heart failure and frailty index: A study based on the National Health and Nutrition Examination Survey from 1999 to 2018

OBJECTIVE: This study aims to explore the association between the frailty index and chronic heart failure (CHF). METHODS: We collected data from the National Health and Nutrition Examination Survey (NHANES) (1998–2018) database to assess the association between CHF and frailty. Demographic, inquiry,...

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Autores principales: Chen, Xiaozhe, Hou, Chunlei, Yao, Lei, Ma, Yulong, Li, Yunfeng, Li, Jianhua, Gui, Mingtai, Wang, Mingzhu, Zhou, Xunjie, Lu, Bo, Fu, Deyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9868664/
https://www.ncbi.nlm.nih.gov/pubmed/36698928
http://dx.doi.org/10.3389/fcvm.2022.1057587
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author Chen, Xiaozhe
Hou, Chunlei
Yao, Lei
Ma, Yulong
Li, Yunfeng
Li, Jianhua
Gui, Mingtai
Wang, Mingzhu
Zhou, Xunjie
Lu, Bo
Fu, Deyu
author_facet Chen, Xiaozhe
Hou, Chunlei
Yao, Lei
Ma, Yulong
Li, Yunfeng
Li, Jianhua
Gui, Mingtai
Wang, Mingzhu
Zhou, Xunjie
Lu, Bo
Fu, Deyu
author_sort Chen, Xiaozhe
collection PubMed
description OBJECTIVE: This study aims to explore the association between the frailty index and chronic heart failure (CHF). METHODS: We collected data from the National Health and Nutrition Examination Survey (NHANES) (1998–2018) database to assess the association between CHF and frailty. Demographic, inquiry, laboratory examinations, and characteristics were gathered to compare CHF and non-CHF groups. Multiple logistic regression analysis was performed to explore the relationship between frailty and CHF. Cox proportional hazards models were used to estimate hazard ratios (HR) and 95% confidence interval (CI) for mortality from all causes and cardiovascular disease (CVD). RESULTS: A total of 16,175 participants with cardiac and cerebrovascular disease were categorized into CHF (n = 1,125) and non-CHF (n = 15,050) groups. In patients with CHF, the prevalence of frailty, pre-frailty, and non-frailty were 66.31, 30.93, and 2.75%, respectively. In multiple logistic regression, patients with CHF who were male (OR = 0.63, 95% CI: 3.11–5.22), whose annual family income was over $20,000 (OR = 0.52, 95% CI: 0.37–0.72, p < 0.001), or with normal hemoglobin level (OR = 0.77, 95% CI: 0.68–0.88, P < 0.001) had a lower likelihood of frailty. CHF patients with hypertension (OR = 3.60, 95% CI: 2.17–5.99, P < 0.0001), coronary heart disease (OR = 1.76, 95% CI: 1.10–2.84, P = 0.02), diabetes mellitus (OR = 1.89, 95% CI: 1.28–2.78, P < 0.001), and stroke (OR = 2.52, 95% CI: 1.53–4.15, P < 0.001) tended to be frail. Survival analysis suggested that pre-frailty and frailty were related to poor all-cause deaths (HR = 1.48, 95% CI: 1.36–1.66; HR = 2.77, 95% CI: 2.40–3.18) and CVD mortality (HR = 1.58, 95% CI: 1.26–1.97; HR = 2.55, 95% CI: 2.02–3.21). CHF patients with frailty were strongly connected with all-cause death (HR = 2.14, 95% CI: 1.27–3.62). CONCLUSION: Frailty was positively associated with CHF. Patients with CHF who were male, whose annual family income was over $20,000, or with normal hemoglobin level were negatively correlated to frailty. For patients with cardiac and cerebrovascular disease as well as CHF, frailty was strongly connected with all-cause death.
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spelling pubmed-98686642023-01-24 The association between chronic heart failure and frailty index: A study based on the National Health and Nutrition Examination Survey from 1999 to 2018 Chen, Xiaozhe Hou, Chunlei Yao, Lei Ma, Yulong Li, Yunfeng Li, Jianhua Gui, Mingtai Wang, Mingzhu Zhou, Xunjie Lu, Bo Fu, Deyu Front Cardiovasc Med Cardiovascular Medicine OBJECTIVE: This study aims to explore the association between the frailty index and chronic heart failure (CHF). METHODS: We collected data from the National Health and Nutrition Examination Survey (NHANES) (1998–2018) database to assess the association between CHF and frailty. Demographic, inquiry, laboratory examinations, and characteristics were gathered to compare CHF and non-CHF groups. Multiple logistic regression analysis was performed to explore the relationship between frailty and CHF. Cox proportional hazards models were used to estimate hazard ratios (HR) and 95% confidence interval (CI) for mortality from all causes and cardiovascular disease (CVD). RESULTS: A total of 16,175 participants with cardiac and cerebrovascular disease were categorized into CHF (n = 1,125) and non-CHF (n = 15,050) groups. In patients with CHF, the prevalence of frailty, pre-frailty, and non-frailty were 66.31, 30.93, and 2.75%, respectively. In multiple logistic regression, patients with CHF who were male (OR = 0.63, 95% CI: 3.11–5.22), whose annual family income was over $20,000 (OR = 0.52, 95% CI: 0.37–0.72, p < 0.001), or with normal hemoglobin level (OR = 0.77, 95% CI: 0.68–0.88, P < 0.001) had a lower likelihood of frailty. CHF patients with hypertension (OR = 3.60, 95% CI: 2.17–5.99, P < 0.0001), coronary heart disease (OR = 1.76, 95% CI: 1.10–2.84, P = 0.02), diabetes mellitus (OR = 1.89, 95% CI: 1.28–2.78, P < 0.001), and stroke (OR = 2.52, 95% CI: 1.53–4.15, P < 0.001) tended to be frail. Survival analysis suggested that pre-frailty and frailty were related to poor all-cause deaths (HR = 1.48, 95% CI: 1.36–1.66; HR = 2.77, 95% CI: 2.40–3.18) and CVD mortality (HR = 1.58, 95% CI: 1.26–1.97; HR = 2.55, 95% CI: 2.02–3.21). CHF patients with frailty were strongly connected with all-cause death (HR = 2.14, 95% CI: 1.27–3.62). CONCLUSION: Frailty was positively associated with CHF. Patients with CHF who were male, whose annual family income was over $20,000, or with normal hemoglobin level were negatively correlated to frailty. For patients with cardiac and cerebrovascular disease as well as CHF, frailty was strongly connected with all-cause death. Frontiers Media S.A. 2023-01-09 /pmc/articles/PMC9868664/ /pubmed/36698928 http://dx.doi.org/10.3389/fcvm.2022.1057587 Text en Copyright © 2023 Chen, Hou, Yao, Ma, Li, Li, Gui, Wang, Zhou, Lu and Fu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Chen, Xiaozhe
Hou, Chunlei
Yao, Lei
Ma, Yulong
Li, Yunfeng
Li, Jianhua
Gui, Mingtai
Wang, Mingzhu
Zhou, Xunjie
Lu, Bo
Fu, Deyu
The association between chronic heart failure and frailty index: A study based on the National Health and Nutrition Examination Survey from 1999 to 2018
title The association between chronic heart failure and frailty index: A study based on the National Health and Nutrition Examination Survey from 1999 to 2018
title_full The association between chronic heart failure and frailty index: A study based on the National Health and Nutrition Examination Survey from 1999 to 2018
title_fullStr The association between chronic heart failure and frailty index: A study based on the National Health and Nutrition Examination Survey from 1999 to 2018
title_full_unstemmed The association between chronic heart failure and frailty index: A study based on the National Health and Nutrition Examination Survey from 1999 to 2018
title_short The association between chronic heart failure and frailty index: A study based on the National Health and Nutrition Examination Survey from 1999 to 2018
title_sort association between chronic heart failure and frailty index: a study based on the national health and nutrition examination survey from 1999 to 2018
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9868664/
https://www.ncbi.nlm.nih.gov/pubmed/36698928
http://dx.doi.org/10.3389/fcvm.2022.1057587
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