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In Vitro Models for the Study of Liver Biology and Diseases: Advances and Limitations

In vitro models of liver (patho)physiology, new technologies, and experimental approaches are progressing rapidly. Based on cell lines, induced pluripotent stem cells or primary cells derived from mouse or human liver as well as whole tissue (slices), such in vitro single- and multicellular models,...

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Autores principales: Kaur, Savneet, Kidambi, Srivatsan, Ortega-Ribera, Martí, Thuy, Le Thi Thanh, Nieto, Natalia, Cogger, Victoria C., Xie, Wei-Fen, Tacke, Frank, Gracia-Sancho, Jordi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9868680/
https://www.ncbi.nlm.nih.gov/pubmed/36442812
http://dx.doi.org/10.1016/j.jcmgh.2022.11.008
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author Kaur, Savneet
Kidambi, Srivatsan
Ortega-Ribera, Martí
Thuy, Le Thi Thanh
Nieto, Natalia
Cogger, Victoria C.
Xie, Wei-Fen
Tacke, Frank
Gracia-Sancho, Jordi
author_facet Kaur, Savneet
Kidambi, Srivatsan
Ortega-Ribera, Martí
Thuy, Le Thi Thanh
Nieto, Natalia
Cogger, Victoria C.
Xie, Wei-Fen
Tacke, Frank
Gracia-Sancho, Jordi
author_sort Kaur, Savneet
collection PubMed
description In vitro models of liver (patho)physiology, new technologies, and experimental approaches are progressing rapidly. Based on cell lines, induced pluripotent stem cells or primary cells derived from mouse or human liver as well as whole tissue (slices), such in vitro single- and multicellular models, including complex microfluidic organ-on-a-chip systems, provide tools to functionally understand mechanisms of liver health and disease. The International Society of Hepatic Sinusoidal Research (ISHSR) commissioned this working group to review the currently available in vitro liver models and describe the advantages and disadvantages of each in the context of evaluating their use for the study of liver functionality, disease modeling, therapeutic discovery, and clinical applicability.
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spelling pubmed-98686802023-01-24 In Vitro Models for the Study of Liver Biology and Diseases: Advances and Limitations Kaur, Savneet Kidambi, Srivatsan Ortega-Ribera, Martí Thuy, Le Thi Thanh Nieto, Natalia Cogger, Victoria C. Xie, Wei-Fen Tacke, Frank Gracia-Sancho, Jordi Cell Mol Gastroenterol Hepatol Review In vitro models of liver (patho)physiology, new technologies, and experimental approaches are progressing rapidly. Based on cell lines, induced pluripotent stem cells or primary cells derived from mouse or human liver as well as whole tissue (slices), such in vitro single- and multicellular models, including complex microfluidic organ-on-a-chip systems, provide tools to functionally understand mechanisms of liver health and disease. The International Society of Hepatic Sinusoidal Research (ISHSR) commissioned this working group to review the currently available in vitro liver models and describe the advantages and disadvantages of each in the context of evaluating their use for the study of liver functionality, disease modeling, therapeutic discovery, and clinical applicability. Elsevier 2022-11-26 /pmc/articles/PMC9868680/ /pubmed/36442812 http://dx.doi.org/10.1016/j.jcmgh.2022.11.008 Text en © 2022 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kaur, Savneet
Kidambi, Srivatsan
Ortega-Ribera, Martí
Thuy, Le Thi Thanh
Nieto, Natalia
Cogger, Victoria C.
Xie, Wei-Fen
Tacke, Frank
Gracia-Sancho, Jordi
In Vitro Models for the Study of Liver Biology and Diseases: Advances and Limitations
title In Vitro Models for the Study of Liver Biology and Diseases: Advances and Limitations
title_full In Vitro Models for the Study of Liver Biology and Diseases: Advances and Limitations
title_fullStr In Vitro Models for the Study of Liver Biology and Diseases: Advances and Limitations
title_full_unstemmed In Vitro Models for the Study of Liver Biology and Diseases: Advances and Limitations
title_short In Vitro Models for the Study of Liver Biology and Diseases: Advances and Limitations
title_sort in vitro models for the study of liver biology and diseases: advances and limitations
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9868680/
https://www.ncbi.nlm.nih.gov/pubmed/36442812
http://dx.doi.org/10.1016/j.jcmgh.2022.11.008
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