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In Vitro Models for the Study of Liver Biology and Diseases: Advances and Limitations
In vitro models of liver (patho)physiology, new technologies, and experimental approaches are progressing rapidly. Based on cell lines, induced pluripotent stem cells or primary cells derived from mouse or human liver as well as whole tissue (slices), such in vitro single- and multicellular models,...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9868680/ https://www.ncbi.nlm.nih.gov/pubmed/36442812 http://dx.doi.org/10.1016/j.jcmgh.2022.11.008 |
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author | Kaur, Savneet Kidambi, Srivatsan Ortega-Ribera, Martí Thuy, Le Thi Thanh Nieto, Natalia Cogger, Victoria C. Xie, Wei-Fen Tacke, Frank Gracia-Sancho, Jordi |
author_facet | Kaur, Savneet Kidambi, Srivatsan Ortega-Ribera, Martí Thuy, Le Thi Thanh Nieto, Natalia Cogger, Victoria C. Xie, Wei-Fen Tacke, Frank Gracia-Sancho, Jordi |
author_sort | Kaur, Savneet |
collection | PubMed |
description | In vitro models of liver (patho)physiology, new technologies, and experimental approaches are progressing rapidly. Based on cell lines, induced pluripotent stem cells or primary cells derived from mouse or human liver as well as whole tissue (slices), such in vitro single- and multicellular models, including complex microfluidic organ-on-a-chip systems, provide tools to functionally understand mechanisms of liver health and disease. The International Society of Hepatic Sinusoidal Research (ISHSR) commissioned this working group to review the currently available in vitro liver models and describe the advantages and disadvantages of each in the context of evaluating their use for the study of liver functionality, disease modeling, therapeutic discovery, and clinical applicability. |
format | Online Article Text |
id | pubmed-9868680 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-98686802023-01-24 In Vitro Models for the Study of Liver Biology and Diseases: Advances and Limitations Kaur, Savneet Kidambi, Srivatsan Ortega-Ribera, Martí Thuy, Le Thi Thanh Nieto, Natalia Cogger, Victoria C. Xie, Wei-Fen Tacke, Frank Gracia-Sancho, Jordi Cell Mol Gastroenterol Hepatol Review In vitro models of liver (patho)physiology, new technologies, and experimental approaches are progressing rapidly. Based on cell lines, induced pluripotent stem cells or primary cells derived from mouse or human liver as well as whole tissue (slices), such in vitro single- and multicellular models, including complex microfluidic organ-on-a-chip systems, provide tools to functionally understand mechanisms of liver health and disease. The International Society of Hepatic Sinusoidal Research (ISHSR) commissioned this working group to review the currently available in vitro liver models and describe the advantages and disadvantages of each in the context of evaluating their use for the study of liver functionality, disease modeling, therapeutic discovery, and clinical applicability. Elsevier 2022-11-26 /pmc/articles/PMC9868680/ /pubmed/36442812 http://dx.doi.org/10.1016/j.jcmgh.2022.11.008 Text en © 2022 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Kaur, Savneet Kidambi, Srivatsan Ortega-Ribera, Martí Thuy, Le Thi Thanh Nieto, Natalia Cogger, Victoria C. Xie, Wei-Fen Tacke, Frank Gracia-Sancho, Jordi In Vitro Models for the Study of Liver Biology and Diseases: Advances and Limitations |
title | In Vitro Models for the Study of Liver Biology and Diseases: Advances and Limitations |
title_full | In Vitro Models for the Study of Liver Biology and Diseases: Advances and Limitations |
title_fullStr | In Vitro Models for the Study of Liver Biology and Diseases: Advances and Limitations |
title_full_unstemmed | In Vitro Models for the Study of Liver Biology and Diseases: Advances and Limitations |
title_short | In Vitro Models for the Study of Liver Biology and Diseases: Advances and Limitations |
title_sort | in vitro models for the study of liver biology and diseases: advances and limitations |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9868680/ https://www.ncbi.nlm.nih.gov/pubmed/36442812 http://dx.doi.org/10.1016/j.jcmgh.2022.11.008 |
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