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Effect of nasal irrigation in adults infected with Omicron variant of COVID-19: A quasi-experimental study
OBJECTIVE: To investigate the effect of nasal irrigation on the duration of symptoms and nucleic acid conversion in adults infected with the Omicron variant of COVID-19. METHODS: This quasi-experimental study enrolled patients diagnosed with asymptomatic, mild, or moderate Omicron infection at the S...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9868717/ https://www.ncbi.nlm.nih.gov/pubmed/36699894 http://dx.doi.org/10.3389/fpubh.2022.1046112 |
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author | Liu, Li Xie, Shuangshuang Li, Cheng Su, Liang Zhu, Chengbao |
author_facet | Liu, Li Xie, Shuangshuang Li, Cheng Su, Liang Zhu, Chengbao |
author_sort | Liu, Li |
collection | PubMed |
description | OBJECTIVE: To investigate the effect of nasal irrigation on the duration of symptoms and nucleic acid conversion in adults infected with the Omicron variant of COVID-19. METHODS: This quasi-experimental study enrolled patients diagnosed with asymptomatic, mild, or moderate Omicron infection at the Shandong Public Health Clinical Center between April 1, 2022 and May 1, 2022. Patients were divided into two groups to receive Lianhua Qingwen granules and traditional Chinese medicine (TCM) prescriptions (conventional group) and 3% hypertonic saline nasal irrigation based on conventional treatment (nasal irrigation groups), respectively. Primary outcomes were symptom disappearance time and nucleic acid negative conversion time. Secondary outcomes were peripheral blood white blood cell (WBC), lymphocyte (LYM) count, neutrophil (NEU) count, C-reactive protein (CRP) level, and chest CT examination findings. RESULTS: Eighty patients were included (40 patients/group). Multiple linear regression analysis showed that, after adjustment for comorbidities, smoking history, LYM count, and Ct values of N gene, the patients in the nasal irrigation group were more likely to get lower nucleic acid negative conversion time (β = −11.052, 95% CI: −8.277–13.827, P < 0.001) compared with the conventional group. The symptom disappearance time showed no significant improvement (P > 0.05). Subgroup analysis for treatment-naïve patients in the nasal irrigation group showed similar nucleic acid negative conversion time improvement (P = 0.038). CONCLUSION: Early nasal irrigation shortens the nucleic acid negative conversion time in adults infected with the Omicron variant but without improvements in symptom disappearance time. |
format | Online Article Text |
id | pubmed-9868717 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98687172023-01-24 Effect of nasal irrigation in adults infected with Omicron variant of COVID-19: A quasi-experimental study Liu, Li Xie, Shuangshuang Li, Cheng Su, Liang Zhu, Chengbao Front Public Health Public Health OBJECTIVE: To investigate the effect of nasal irrigation on the duration of symptoms and nucleic acid conversion in adults infected with the Omicron variant of COVID-19. METHODS: This quasi-experimental study enrolled patients diagnosed with asymptomatic, mild, or moderate Omicron infection at the Shandong Public Health Clinical Center between April 1, 2022 and May 1, 2022. Patients were divided into two groups to receive Lianhua Qingwen granules and traditional Chinese medicine (TCM) prescriptions (conventional group) and 3% hypertonic saline nasal irrigation based on conventional treatment (nasal irrigation groups), respectively. Primary outcomes were symptom disappearance time and nucleic acid negative conversion time. Secondary outcomes were peripheral blood white blood cell (WBC), lymphocyte (LYM) count, neutrophil (NEU) count, C-reactive protein (CRP) level, and chest CT examination findings. RESULTS: Eighty patients were included (40 patients/group). Multiple linear regression analysis showed that, after adjustment for comorbidities, smoking history, LYM count, and Ct values of N gene, the patients in the nasal irrigation group were more likely to get lower nucleic acid negative conversion time (β = −11.052, 95% CI: −8.277–13.827, P < 0.001) compared with the conventional group. The symptom disappearance time showed no significant improvement (P > 0.05). Subgroup analysis for treatment-naïve patients in the nasal irrigation group showed similar nucleic acid negative conversion time improvement (P = 0.038). CONCLUSION: Early nasal irrigation shortens the nucleic acid negative conversion time in adults infected with the Omicron variant but without improvements in symptom disappearance time. Frontiers Media S.A. 2023-01-09 /pmc/articles/PMC9868717/ /pubmed/36699894 http://dx.doi.org/10.3389/fpubh.2022.1046112 Text en Copyright © 2023 Liu, Xie, Li, Su and Zhu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Public Health Liu, Li Xie, Shuangshuang Li, Cheng Su, Liang Zhu, Chengbao Effect of nasal irrigation in adults infected with Omicron variant of COVID-19: A quasi-experimental study |
title | Effect of nasal irrigation in adults infected with Omicron variant of COVID-19: A quasi-experimental study |
title_full | Effect of nasal irrigation in adults infected with Omicron variant of COVID-19: A quasi-experimental study |
title_fullStr | Effect of nasal irrigation in adults infected with Omicron variant of COVID-19: A quasi-experimental study |
title_full_unstemmed | Effect of nasal irrigation in adults infected with Omicron variant of COVID-19: A quasi-experimental study |
title_short | Effect of nasal irrigation in adults infected with Omicron variant of COVID-19: A quasi-experimental study |
title_sort | effect of nasal irrigation in adults infected with omicron variant of covid-19: a quasi-experimental study |
topic | Public Health |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9868717/ https://www.ncbi.nlm.nih.gov/pubmed/36699894 http://dx.doi.org/10.3389/fpubh.2022.1046112 |
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