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Altered brain connectivity in hyperkinetic movement disorders: A review of resting-state fMRI

BACKGROUND: Hyperkinetic movement disorders (HMD) manifest as abnormal and uncontrollable movements. Despite reported involvement of several neural circuits, exact connectivity profiles remain elusive. OBJECTIVES: Providing a comprehensive literature review of resting-state brain connectivity altera...

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Autores principales: Marapin, Ramesh S., van der Horn, Harm J., Madelein van der Stouwe, A.M., Dalenberg, Jelle R., de Jong, Bauke M., Tijssen, Marina A.J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9868884/
https://www.ncbi.nlm.nih.gov/pubmed/36669351
http://dx.doi.org/10.1016/j.nicl.2022.103302
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author Marapin, Ramesh S.
van der Horn, Harm J.
Madelein van der Stouwe, A.M.
Dalenberg, Jelle R.
de Jong, Bauke M.
Tijssen, Marina A.J.
author_facet Marapin, Ramesh S.
van der Horn, Harm J.
Madelein van der Stouwe, A.M.
Dalenberg, Jelle R.
de Jong, Bauke M.
Tijssen, Marina A.J.
author_sort Marapin, Ramesh S.
collection PubMed
description BACKGROUND: Hyperkinetic movement disorders (HMD) manifest as abnormal and uncontrollable movements. Despite reported involvement of several neural circuits, exact connectivity profiles remain elusive. OBJECTIVES: Providing a comprehensive literature review of resting-state brain connectivity alterations using resting-state fMRI (rs-fMRI). We additionally discuss alterations from the perspective of brain networks, as well as correlations between connectivity and clinical measures. METHODS: A systematic review was performed according to PRISMA guidelines and searching PubMed until October 2022. Rs-fMRI studies addressing ataxia, chorea, dystonia, myoclonus, tics, tremor, and functional movement disorders (FMD) were included. The standardized mean difference was used to summarize findings per region in the Automated Anatomical Labeling atlas for each phenotype. Furthermore, the activation likelihood estimation meta-analytic method was used to analyze convergence of significant between-group differences per phenotype. Finally, we conducted hierarchical cluster analysis to provide additional insights into commonalities and differences across HMD phenotypes. RESULTS: Most articles concerned tremor (51), followed by dystonia (46), tics (19), chorea (12), myoclonus (11), FMD (11), and ataxia (8). Altered resting-state connectivity was found in several brain regions: in ataxia mainly cerebellar areas; for chorea, the caudate nucleus; for dystonia, sensorimotor and basal ganglia regions; for myoclonus, the thalamus and cingulate cortex; in tics, the basal ganglia, cerebellum, insula, and frontal cortex; for tremor, the cerebello-thalamo-cortical circuit; finally, in FMD, frontal, parietal, and cerebellar regions. Both decreased and increased connectivity were found for all HMD. Significant spatial convergence was found for dystonia, FMD, myoclonus, and tremor. Correlations between clinical measures and resting-state connectivity were frequently described. CONCLUSION: Key brain regions contributing to functional connectivity changes across HMD often overlap. Possible increases and decreases of functional connections of a specific region emphasize that HMD should be viewed as a network disorder. Despite the complex interplay of physiological and methodological factors, this review serves to gain insight in brain connectivity profiles across HMD phenotypes.
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spelling pubmed-98688842023-01-24 Altered brain connectivity in hyperkinetic movement disorders: A review of resting-state fMRI Marapin, Ramesh S. van der Horn, Harm J. Madelein van der Stouwe, A.M. Dalenberg, Jelle R. de Jong, Bauke M. Tijssen, Marina A.J. Neuroimage Clin Review Article BACKGROUND: Hyperkinetic movement disorders (HMD) manifest as abnormal and uncontrollable movements. Despite reported involvement of several neural circuits, exact connectivity profiles remain elusive. OBJECTIVES: Providing a comprehensive literature review of resting-state brain connectivity alterations using resting-state fMRI (rs-fMRI). We additionally discuss alterations from the perspective of brain networks, as well as correlations between connectivity and clinical measures. METHODS: A systematic review was performed according to PRISMA guidelines and searching PubMed until October 2022. Rs-fMRI studies addressing ataxia, chorea, dystonia, myoclonus, tics, tremor, and functional movement disorders (FMD) were included. The standardized mean difference was used to summarize findings per region in the Automated Anatomical Labeling atlas for each phenotype. Furthermore, the activation likelihood estimation meta-analytic method was used to analyze convergence of significant between-group differences per phenotype. Finally, we conducted hierarchical cluster analysis to provide additional insights into commonalities and differences across HMD phenotypes. RESULTS: Most articles concerned tremor (51), followed by dystonia (46), tics (19), chorea (12), myoclonus (11), FMD (11), and ataxia (8). Altered resting-state connectivity was found in several brain regions: in ataxia mainly cerebellar areas; for chorea, the caudate nucleus; for dystonia, sensorimotor and basal ganglia regions; for myoclonus, the thalamus and cingulate cortex; in tics, the basal ganglia, cerebellum, insula, and frontal cortex; for tremor, the cerebello-thalamo-cortical circuit; finally, in FMD, frontal, parietal, and cerebellar regions. Both decreased and increased connectivity were found for all HMD. Significant spatial convergence was found for dystonia, FMD, myoclonus, and tremor. Correlations between clinical measures and resting-state connectivity were frequently described. CONCLUSION: Key brain regions contributing to functional connectivity changes across HMD often overlap. Possible increases and decreases of functional connections of a specific region emphasize that HMD should be viewed as a network disorder. Despite the complex interplay of physiological and methodological factors, this review serves to gain insight in brain connectivity profiles across HMD phenotypes. Elsevier 2022-12-24 /pmc/articles/PMC9868884/ /pubmed/36669351 http://dx.doi.org/10.1016/j.nicl.2022.103302 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review Article
Marapin, Ramesh S.
van der Horn, Harm J.
Madelein van der Stouwe, A.M.
Dalenberg, Jelle R.
de Jong, Bauke M.
Tijssen, Marina A.J.
Altered brain connectivity in hyperkinetic movement disorders: A review of resting-state fMRI
title Altered brain connectivity in hyperkinetic movement disorders: A review of resting-state fMRI
title_full Altered brain connectivity in hyperkinetic movement disorders: A review of resting-state fMRI
title_fullStr Altered brain connectivity in hyperkinetic movement disorders: A review of resting-state fMRI
title_full_unstemmed Altered brain connectivity in hyperkinetic movement disorders: A review of resting-state fMRI
title_short Altered brain connectivity in hyperkinetic movement disorders: A review of resting-state fMRI
title_sort altered brain connectivity in hyperkinetic movement disorders: a review of resting-state fmri
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9868884/
https://www.ncbi.nlm.nih.gov/pubmed/36669351
http://dx.doi.org/10.1016/j.nicl.2022.103302
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