Cargando…

Moderate level platelet count might be a good prognostic indicator for intra-abdominal infection in acute pancreatitis: A retrospective cohort study of 1,363 patients

BACKGROUND: Early recognition of the risk factors is important for acute pancreatitis management. The aim of this study is to investigate the relationship between platelet count and clinical outcomes in patients with acute pancreatitis. METHODS: The data are collected from a university-affiliated ho...

Descripción completa

Detalles Bibliográficos
Autores principales: Sun, Wenwu, Huang, Jun, Ni, Tongtian, Wen, Yi, Menglu, Gui, Yongguo, Wang, Yanbin, Zhao, Sheng, Huiqiu, Chen, Ying, Ma, Li, Zhao, Bing, Mao, Enqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9868935/
https://www.ncbi.nlm.nih.gov/pubmed/36698839
http://dx.doi.org/10.3389/fmed.2022.1077076
_version_ 1784876656712744960
author Sun, Wenwu
Huang, Jun
Ni, Tongtian
Wen, Yi
Menglu, Gui
Yongguo, Wang
Yanbin, Zhao
Sheng, Huiqiu
Chen, Ying
Ma, Li
Zhao, Bing
Mao, Enqiang
author_facet Sun, Wenwu
Huang, Jun
Ni, Tongtian
Wen, Yi
Menglu, Gui
Yongguo, Wang
Yanbin, Zhao
Sheng, Huiqiu
Chen, Ying
Ma, Li
Zhao, Bing
Mao, Enqiang
author_sort Sun, Wenwu
collection PubMed
description BACKGROUND: Early recognition of the risk factors is important for acute pancreatitis management. The aim of this study is to investigate the relationship between platelet count and clinical outcomes in patients with acute pancreatitis. METHODS: The data are collected from a university-affiliated hospital between January 2013 and December 2020. A generalized additive model and a two-piecewise linear regression model are used to estimate the association between platelet count and the risks of intra-abdominal infection, surgical intervention, in-hospital mortality, and length of hospital stay. RESULTS: Among the 1,363 patients, 99 (7.3%) patients suffered intra-abdominal infection, 190 (13.9%) patients underwent surgical intervention, and 38 (2.8%) patients died in the hospital. The median length of hospital stay is 21 days. Generalized additive model and two-piecewise linear regression analysis show that the risk of intra-abdominal infection decreases as the platelet count increases to 160 × 10(9)/L (OR: 0.991, 95% CI: 0.984–0.998, p = 0.015) and then increases as the platelet count levels up (OR: 1.007, 95% CI: 1.004–1.010, p < 0.001). The trend is similar to the risk of surgical intervention and length of hospital stay. Even though there seems a declining trend in mortality, no significant association is found after adjustment for potential confounders. Further analysis shows that changes in platelet count within the first 3 days after admission have no obvious association with clinical outcomes. CONCLUSION: A platelet count of approximately 160 × 10(9)/L on admission is associated with the lowest risk of intra-abdominal infection, surgical intervention, and shortest hospital stay in patients with acute pancreatitis.
format Online
Article
Text
id pubmed-9868935
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-98689352023-01-24 Moderate level platelet count might be a good prognostic indicator for intra-abdominal infection in acute pancreatitis: A retrospective cohort study of 1,363 patients Sun, Wenwu Huang, Jun Ni, Tongtian Wen, Yi Menglu, Gui Yongguo, Wang Yanbin, Zhao Sheng, Huiqiu Chen, Ying Ma, Li Zhao, Bing Mao, Enqiang Front Med (Lausanne) Medicine BACKGROUND: Early recognition of the risk factors is important for acute pancreatitis management. The aim of this study is to investigate the relationship between platelet count and clinical outcomes in patients with acute pancreatitis. METHODS: The data are collected from a university-affiliated hospital between January 2013 and December 2020. A generalized additive model and a two-piecewise linear regression model are used to estimate the association between platelet count and the risks of intra-abdominal infection, surgical intervention, in-hospital mortality, and length of hospital stay. RESULTS: Among the 1,363 patients, 99 (7.3%) patients suffered intra-abdominal infection, 190 (13.9%) patients underwent surgical intervention, and 38 (2.8%) patients died in the hospital. The median length of hospital stay is 21 days. Generalized additive model and two-piecewise linear regression analysis show that the risk of intra-abdominal infection decreases as the platelet count increases to 160 × 10(9)/L (OR: 0.991, 95% CI: 0.984–0.998, p = 0.015) and then increases as the platelet count levels up (OR: 1.007, 95% CI: 1.004–1.010, p < 0.001). The trend is similar to the risk of surgical intervention and length of hospital stay. Even though there seems a declining trend in mortality, no significant association is found after adjustment for potential confounders. Further analysis shows that changes in platelet count within the first 3 days after admission have no obvious association with clinical outcomes. CONCLUSION: A platelet count of approximately 160 × 10(9)/L on admission is associated with the lowest risk of intra-abdominal infection, surgical intervention, and shortest hospital stay in patients with acute pancreatitis. Frontiers Media S.A. 2023-01-09 /pmc/articles/PMC9868935/ /pubmed/36698839 http://dx.doi.org/10.3389/fmed.2022.1077076 Text en Copyright © 2023 Sun, Huang, Ni, Wen, Menglu, Yongguo, Yanbin, Sheng, Chen, Ma, Zhao and Mao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Sun, Wenwu
Huang, Jun
Ni, Tongtian
Wen, Yi
Menglu, Gui
Yongguo, Wang
Yanbin, Zhao
Sheng, Huiqiu
Chen, Ying
Ma, Li
Zhao, Bing
Mao, Enqiang
Moderate level platelet count might be a good prognostic indicator for intra-abdominal infection in acute pancreatitis: A retrospective cohort study of 1,363 patients
title Moderate level platelet count might be a good prognostic indicator for intra-abdominal infection in acute pancreatitis: A retrospective cohort study of 1,363 patients
title_full Moderate level platelet count might be a good prognostic indicator for intra-abdominal infection in acute pancreatitis: A retrospective cohort study of 1,363 patients
title_fullStr Moderate level platelet count might be a good prognostic indicator for intra-abdominal infection in acute pancreatitis: A retrospective cohort study of 1,363 patients
title_full_unstemmed Moderate level platelet count might be a good prognostic indicator for intra-abdominal infection in acute pancreatitis: A retrospective cohort study of 1,363 patients
title_short Moderate level platelet count might be a good prognostic indicator for intra-abdominal infection in acute pancreatitis: A retrospective cohort study of 1,363 patients
title_sort moderate level platelet count might be a good prognostic indicator for intra-abdominal infection in acute pancreatitis: a retrospective cohort study of 1,363 patients
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9868935/
https://www.ncbi.nlm.nih.gov/pubmed/36698839
http://dx.doi.org/10.3389/fmed.2022.1077076
work_keys_str_mv AT sunwenwu moderatelevelplateletcountmightbeagoodprognosticindicatorforintraabdominalinfectioninacutepancreatitisaretrospectivecohortstudyof1363patients
AT huangjun moderatelevelplateletcountmightbeagoodprognosticindicatorforintraabdominalinfectioninacutepancreatitisaretrospectivecohortstudyof1363patients
AT nitongtian moderatelevelplateletcountmightbeagoodprognosticindicatorforintraabdominalinfectioninacutepancreatitisaretrospectivecohortstudyof1363patients
AT wenyi moderatelevelplateletcountmightbeagoodprognosticindicatorforintraabdominalinfectioninacutepancreatitisaretrospectivecohortstudyof1363patients
AT menglugui moderatelevelplateletcountmightbeagoodprognosticindicatorforintraabdominalinfectioninacutepancreatitisaretrospectivecohortstudyof1363patients
AT yongguowang moderatelevelplateletcountmightbeagoodprognosticindicatorforintraabdominalinfectioninacutepancreatitisaretrospectivecohortstudyof1363patients
AT yanbinzhao moderatelevelplateletcountmightbeagoodprognosticindicatorforintraabdominalinfectioninacutepancreatitisaretrospectivecohortstudyof1363patients
AT shenghuiqiu moderatelevelplateletcountmightbeagoodprognosticindicatorforintraabdominalinfectioninacutepancreatitisaretrospectivecohortstudyof1363patients
AT chenying moderatelevelplateletcountmightbeagoodprognosticindicatorforintraabdominalinfectioninacutepancreatitisaretrospectivecohortstudyof1363patients
AT mali moderatelevelplateletcountmightbeagoodprognosticindicatorforintraabdominalinfectioninacutepancreatitisaretrospectivecohortstudyof1363patients
AT zhaobing moderatelevelplateletcountmightbeagoodprognosticindicatorforintraabdominalinfectioninacutepancreatitisaretrospectivecohortstudyof1363patients
AT maoenqiang moderatelevelplateletcountmightbeagoodprognosticindicatorforintraabdominalinfectioninacutepancreatitisaretrospectivecohortstudyof1363patients