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The frequency of somatic mutations in cancer predicts the phenotypic relevance of germline mutations
Genomic sequence mutations can be pathogenic in both germline and somatic cells. Several authors have observed that often the same genes are involved in cancer when mutated in somatic cells and in genetic diseases when mutated in the germline. Recent advances in high-throughput sequencing techniques...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9868957/ https://www.ncbi.nlm.nih.gov/pubmed/36699457 http://dx.doi.org/10.3389/fgene.2022.1045301 |