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Emergence of human-porcine reassortment G9P[19] porcine rotavirus A strain in Guangdong Province, China

Group A rotaviruses of the family Reoviridae is one of the important intestinal pathogens causing diarrhea in piglets and humans. A human-porcine reassortment rotavirus, GDJM1, was identified from outbreak of diarrhea in suckling piglets and it associated with 60.00% (324/540) morbidity and 20.99% (...

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Autores principales: Luo, Shicheng, Chen, Xiuqiao, Yan, Guangzhi, Chen, Shengnan, Pan, Jinghua, Zeng, Mengyi, Han, Hui, Guo, Yajing, Zhang, Haoquan, Li, Jiaming, Mo, Meilian, Liu, Mingjie, Huang, Liangzong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9868962/
https://www.ncbi.nlm.nih.gov/pubmed/36699335
http://dx.doi.org/10.3389/fvets.2022.1111919
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author Luo, Shicheng
Chen, Xiuqiao
Yan, Guangzhi
Chen, Shengnan
Pan, Jinghua
Zeng, Mengyi
Han, Hui
Guo, Yajing
Zhang, Haoquan
Li, Jiaming
Mo, Meilian
Liu, Mingjie
Huang, Liangzong
author_facet Luo, Shicheng
Chen, Xiuqiao
Yan, Guangzhi
Chen, Shengnan
Pan, Jinghua
Zeng, Mengyi
Han, Hui
Guo, Yajing
Zhang, Haoquan
Li, Jiaming
Mo, Meilian
Liu, Mingjie
Huang, Liangzong
author_sort Luo, Shicheng
collection PubMed
description Group A rotaviruses of the family Reoviridae is one of the important intestinal pathogens causing diarrhea in piglets and humans. A human-porcine reassortment rotavirus, GDJM1, was identified from outbreak of diarrhea in suckling piglets and it associated with 60.00% (324/540) morbidity and 20.99% (68/324) mortality in Guangdong Province of China in 2022. Thus, to further characterize the evolutionary diversity of GDJM1, all gene segments were analyzed. The genome constellation was G9-P[19]-I5-R1-C1-M1-A8-N1-T1-E1-H1. Nucleotide sequence identity and phylogenetic analyses showed that the VP6, VP7, NSP4 and NSP5 genes of GDJM1 were the most closely related to the respective genes of porcine strains, with the highest homology ranging from 95.65–98.55% identity. The remaining seven genes (VP1-VP4, NSP1-NSP3) were the most closely related to human strains, with the highest homology ranging from 91.83–96.69% similarity. Therefore, it is likely that GDJM1 emerged as the result of genetic reassortment between porcine and human rotaviruses. To our knowledge, this is the first report that a human-porcine reassortment G9P[19] RVA strain has been identified in mainland China, which providing important insights into evolutionary characterization of G9P[19] RVA strain, and reveals that the strain has a potential risk of cross-species transmission.
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spelling pubmed-98689622023-01-24 Emergence of human-porcine reassortment G9P[19] porcine rotavirus A strain in Guangdong Province, China Luo, Shicheng Chen, Xiuqiao Yan, Guangzhi Chen, Shengnan Pan, Jinghua Zeng, Mengyi Han, Hui Guo, Yajing Zhang, Haoquan Li, Jiaming Mo, Meilian Liu, Mingjie Huang, Liangzong Front Vet Sci Veterinary Science Group A rotaviruses of the family Reoviridae is one of the important intestinal pathogens causing diarrhea in piglets and humans. A human-porcine reassortment rotavirus, GDJM1, was identified from outbreak of diarrhea in suckling piglets and it associated with 60.00% (324/540) morbidity and 20.99% (68/324) mortality in Guangdong Province of China in 2022. Thus, to further characterize the evolutionary diversity of GDJM1, all gene segments were analyzed. The genome constellation was G9-P[19]-I5-R1-C1-M1-A8-N1-T1-E1-H1. Nucleotide sequence identity and phylogenetic analyses showed that the VP6, VP7, NSP4 and NSP5 genes of GDJM1 were the most closely related to the respective genes of porcine strains, with the highest homology ranging from 95.65–98.55% identity. The remaining seven genes (VP1-VP4, NSP1-NSP3) were the most closely related to human strains, with the highest homology ranging from 91.83–96.69% similarity. Therefore, it is likely that GDJM1 emerged as the result of genetic reassortment between porcine and human rotaviruses. To our knowledge, this is the first report that a human-porcine reassortment G9P[19] RVA strain has been identified in mainland China, which providing important insights into evolutionary characterization of G9P[19] RVA strain, and reveals that the strain has a potential risk of cross-species transmission. Frontiers Media S.A. 2023-01-09 /pmc/articles/PMC9868962/ /pubmed/36699335 http://dx.doi.org/10.3389/fvets.2022.1111919 Text en Copyright © 2023 Luo, Chen, Yan, Chen, Pan, Zeng, Han, Guo, Zhang, Li, Mo, Liu and Huang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
Luo, Shicheng
Chen, Xiuqiao
Yan, Guangzhi
Chen, Shengnan
Pan, Jinghua
Zeng, Mengyi
Han, Hui
Guo, Yajing
Zhang, Haoquan
Li, Jiaming
Mo, Meilian
Liu, Mingjie
Huang, Liangzong
Emergence of human-porcine reassortment G9P[19] porcine rotavirus A strain in Guangdong Province, China
title Emergence of human-porcine reassortment G9P[19] porcine rotavirus A strain in Guangdong Province, China
title_full Emergence of human-porcine reassortment G9P[19] porcine rotavirus A strain in Guangdong Province, China
title_fullStr Emergence of human-porcine reassortment G9P[19] porcine rotavirus A strain in Guangdong Province, China
title_full_unstemmed Emergence of human-porcine reassortment G9P[19] porcine rotavirus A strain in Guangdong Province, China
title_short Emergence of human-porcine reassortment G9P[19] porcine rotavirus A strain in Guangdong Province, China
title_sort emergence of human-porcine reassortment g9p[19] porcine rotavirus a strain in guangdong province, china
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9868962/
https://www.ncbi.nlm.nih.gov/pubmed/36699335
http://dx.doi.org/10.3389/fvets.2022.1111919
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