Cargando…
CAR T cell therapy becomes CHIC: “cytokine help intensified CAR” T cells
Chimeric antigen receptors (CARs) in the canonical “second generation” format provide two signals for inducing T cell effector functions; the primary “signal-1” is provided through the TCR CD3ζ chain and the “signal-2” through a linked costimulatory domain to augment activation. While therapy with s...
| Autores principales: | , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2023
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9869021/ https://www.ncbi.nlm.nih.gov/pubmed/36700225 http://dx.doi.org/10.3389/fimmu.2022.1090959 |