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CAR T cell therapy becomes CHIC: “cytokine help intensified CAR” T cells

Chimeric antigen receptors (CARs) in the canonical “second generation” format provide two signals for inducing T cell effector functions; the primary “signal-1” is provided through the TCR CD3ζ chain and the “signal-2” through a linked costimulatory domain to augment activation. While therapy with s...

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Detalles Bibliográficos
Autores principales:	Thomas, Simone, Abken, Hinrich
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9869021/ https://www.ncbi.nlm.nih.gov/pubmed/36700225 http://dx.doi.org/10.3389/fimmu.2022.1090959

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