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Hypothalamic-pituitary-adrenal axis and renin-angiotensin-aldosterone system in adulthood PTSD and childhood maltreatment history

Accumulated evidence shows that psychological trauma and posttraumatic stress disorder (PTSD) are associated with dysfunction in the hypothalamic-pituitary-adrenal (HPA) axis. Besides the HPA axis hormones, recent evidence suggests that the renin-angiotensin-aldosterone (RAA) system and genetic fact...

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Autores principales: Kakehi, Ryoko, Hori, Hiroaki, Yoshida, Fuyuko, Itoh, Mariko, Lin, Mingming, Niwa, Madoka, Narita, Megumi, Ino, Keiko, Imai, Risa, Sasayama, Daimei, Kamo, Toshiko, Kunugi, Hiroshi, Kim, Yoshiharu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9869036/
https://www.ncbi.nlm.nih.gov/pubmed/36699501
http://dx.doi.org/10.3389/fpsyt.2022.967779
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author Kakehi, Ryoko
Hori, Hiroaki
Yoshida, Fuyuko
Itoh, Mariko
Lin, Mingming
Niwa, Madoka
Narita, Megumi
Ino, Keiko
Imai, Risa
Sasayama, Daimei
Kamo, Toshiko
Kunugi, Hiroshi
Kim, Yoshiharu
author_facet Kakehi, Ryoko
Hori, Hiroaki
Yoshida, Fuyuko
Itoh, Mariko
Lin, Mingming
Niwa, Madoka
Narita, Megumi
Ino, Keiko
Imai, Risa
Sasayama, Daimei
Kamo, Toshiko
Kunugi, Hiroshi
Kim, Yoshiharu
author_sort Kakehi, Ryoko
collection PubMed
description Accumulated evidence shows that psychological trauma and posttraumatic stress disorder (PTSD) are associated with dysfunction in the hypothalamic-pituitary-adrenal (HPA) axis. Besides the HPA axis hormones, recent evidence suggests that the renin-angiotensin-aldosterone (RAA) system and genetic factors may be involved in trauma/PTSD as well as in HPA axis regulation. This study attempted to better understand the HPA axis function in relation to PTSD and childhood maltreatment by simultaneously examining RAA system and genetic polymorphisms of candidate genes. Here we studied 69 civilian women with PTSD and 107 healthy control women without DSM-IV-based traumatic experience. Childhood maltreatment history was assessed with the Childhood Trauma Questionnaire. PTSD severity was assessed with the Posttraumatic Diagnostic Scale. Functional disability was assessed with the Sheehan Disability Scale. HPA axis was examined by measuring blood levels of cortisol, adrenocorticotropic hormone, and dehydroepiandrosterone-sulphate (DHEA-S). RAA system was examined by measuring blood renin and aldosterone levels. The FKBP5 rs1360780 and CACNA1C rs1006737 polymorphisms were genotyped. No significant differences were seen between patients and controls in any of the five hormone levels. DHEA-S levels were significantly negatively correlated with overall PTSD severity (p = 0.003) and functional disability (p = 0.008). A two-way analysis of variance with diagnostic groups and genotypes as fixed factors revealed that patients with the rs1006737 A-allele had significantly lower DHEA-S levels than patients with the GG genotype (p = 0.002) and controls with the A-allele (p = 0.006). Childhood maltreatment history was not significantly correlated with any of the five hormone levels. These results were generally unchanged after controlling for the potentially confounding effect of age, depression, and anxiety. Our findings suggest that lower DHEA-S levels could indicate more severe subtype of PTSD, the association of which might be partly modified by the CACNA1C polymorphism.
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spelling pubmed-98690362023-01-24 Hypothalamic-pituitary-adrenal axis and renin-angiotensin-aldosterone system in adulthood PTSD and childhood maltreatment history Kakehi, Ryoko Hori, Hiroaki Yoshida, Fuyuko Itoh, Mariko Lin, Mingming Niwa, Madoka Narita, Megumi Ino, Keiko Imai, Risa Sasayama, Daimei Kamo, Toshiko Kunugi, Hiroshi Kim, Yoshiharu Front Psychiatry Psychiatry Accumulated evidence shows that psychological trauma and posttraumatic stress disorder (PTSD) are associated with dysfunction in the hypothalamic-pituitary-adrenal (HPA) axis. Besides the HPA axis hormones, recent evidence suggests that the renin-angiotensin-aldosterone (RAA) system and genetic factors may be involved in trauma/PTSD as well as in HPA axis regulation. This study attempted to better understand the HPA axis function in relation to PTSD and childhood maltreatment by simultaneously examining RAA system and genetic polymorphisms of candidate genes. Here we studied 69 civilian women with PTSD and 107 healthy control women without DSM-IV-based traumatic experience. Childhood maltreatment history was assessed with the Childhood Trauma Questionnaire. PTSD severity was assessed with the Posttraumatic Diagnostic Scale. Functional disability was assessed with the Sheehan Disability Scale. HPA axis was examined by measuring blood levels of cortisol, adrenocorticotropic hormone, and dehydroepiandrosterone-sulphate (DHEA-S). RAA system was examined by measuring blood renin and aldosterone levels. The FKBP5 rs1360780 and CACNA1C rs1006737 polymorphisms were genotyped. No significant differences were seen between patients and controls in any of the five hormone levels. DHEA-S levels were significantly negatively correlated with overall PTSD severity (p = 0.003) and functional disability (p = 0.008). A two-way analysis of variance with diagnostic groups and genotypes as fixed factors revealed that patients with the rs1006737 A-allele had significantly lower DHEA-S levels than patients with the GG genotype (p = 0.002) and controls with the A-allele (p = 0.006). Childhood maltreatment history was not significantly correlated with any of the five hormone levels. These results were generally unchanged after controlling for the potentially confounding effect of age, depression, and anxiety. Our findings suggest that lower DHEA-S levels could indicate more severe subtype of PTSD, the association of which might be partly modified by the CACNA1C polymorphism. Frontiers Media S.A. 2023-01-09 /pmc/articles/PMC9869036/ /pubmed/36699501 http://dx.doi.org/10.3389/fpsyt.2022.967779 Text en Copyright © 2023 Kakehi, Hori, Yoshida, Itoh, Lin, Niwa, Narita, Ino, Imai, Sasayama, Kamo, Kunugi and Kim. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Kakehi, Ryoko
Hori, Hiroaki
Yoshida, Fuyuko
Itoh, Mariko
Lin, Mingming
Niwa, Madoka
Narita, Megumi
Ino, Keiko
Imai, Risa
Sasayama, Daimei
Kamo, Toshiko
Kunugi, Hiroshi
Kim, Yoshiharu
Hypothalamic-pituitary-adrenal axis and renin-angiotensin-aldosterone system in adulthood PTSD and childhood maltreatment history
title Hypothalamic-pituitary-adrenal axis and renin-angiotensin-aldosterone system in adulthood PTSD and childhood maltreatment history
title_full Hypothalamic-pituitary-adrenal axis and renin-angiotensin-aldosterone system in adulthood PTSD and childhood maltreatment history
title_fullStr Hypothalamic-pituitary-adrenal axis and renin-angiotensin-aldosterone system in adulthood PTSD and childhood maltreatment history
title_full_unstemmed Hypothalamic-pituitary-adrenal axis and renin-angiotensin-aldosterone system in adulthood PTSD and childhood maltreatment history
title_short Hypothalamic-pituitary-adrenal axis and renin-angiotensin-aldosterone system in adulthood PTSD and childhood maltreatment history
title_sort hypothalamic-pituitary-adrenal axis and renin-angiotensin-aldosterone system in adulthood ptsd and childhood maltreatment history
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9869036/
https://www.ncbi.nlm.nih.gov/pubmed/36699501
http://dx.doi.org/10.3389/fpsyt.2022.967779
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