Mapping of foot-and-mouth disease virus antigenic sites recognized by single-domain antibodies reveals different 146S particle specific sites and particle flexibility

Vaccination with intact (146S) foot-and-mouth disease virus (FMDV) particles is used to control FMD. However, 146S particles easily dissociate into stable pentameric 12S particles which are less immunogenic. We earlier isolated several single-domain antibody fragments (VHHs) that specifically bind e...

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Detalles Bibliográficos
Autores principales: Harmsen, Michiel M., Li, Haozhou, Sun, Shiqi, van der Poel, Wim H. M., Dekker, Aldo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Veterinary Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9869066/
https://www.ncbi.nlm.nih.gov/pubmed/36699337
http://dx.doi.org/10.3389/fvets.2022.1040802

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