Chronic Δ9-tetrahydrocannabinol impact on plasticity, and differential activation requirement for CB1-dependent long-term depression in ventral tegmental area GABA neurons in adult versus young mice

The ventral tegmental area (VTA) mediates incentive salience and reward prediction error through dopamine (DA) neurons that are regulated by local VTA GABA neurons. In young mice, VTA GABA cells exhibit a form of synaptic plasticity known as long-term depression (LTD) that is dependent on cannabinoi...

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Detalles Bibliográficos
Autores principales: Ostlund, Isaac, Von Gunten, Michael, Smith, Calvin, Edwards, Jeffrey G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9869137/
https://www.ncbi.nlm.nih.gov/pubmed/36699526
http://dx.doi.org/10.3389/fnins.2022.1067493

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