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Prothrombin Time and Coagulation Factor IX as Hemostatic Risk Markers for Legg– Calvé–Perthes Disease

BACKGROUND: Legg–Calvé–Perthes disease (LCPD) is a pediatric disorder that occurs due to the avascular necrosis of the femoral head and affects the range of motion of the hip in various degrees. Its etiology is still unknown, although it has been associated with coagulation abnormalities, however, t...

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Autores principales: Hernández-Zamora, Edgar, Rodríguez-Olivas, Armando Odiseo, Rosales-Cruz, Erika, Galicia-Alvarado, Marlene Alejandra, Zavala-Hernández, Cesar, Reyes-Maldonado, Elba
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9869215/
https://www.ncbi.nlm.nih.gov/pubmed/36650707
http://dx.doi.org/10.1177/10760296221151166
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author Hernández-Zamora, Edgar
Rodríguez-Olivas, Armando Odiseo
Rosales-Cruz, Erika
Galicia-Alvarado, Marlene Alejandra
Zavala-Hernández, Cesar
Reyes-Maldonado, Elba
author_facet Hernández-Zamora, Edgar
Rodríguez-Olivas, Armando Odiseo
Rosales-Cruz, Erika
Galicia-Alvarado, Marlene Alejandra
Zavala-Hernández, Cesar
Reyes-Maldonado, Elba
author_sort Hernández-Zamora, Edgar
collection PubMed
description BACKGROUND: Legg–Calvé–Perthes disease (LCPD) is a pediatric disorder that occurs due to the avascular necrosis of the femoral head and affects the range of motion of the hip in various degrees. Its etiology is still unknown, although it has been associated with coagulation abnormalities, however, the lack of reproducibility in the results in various studies has created a controversy as to whether hemostasis disorders are related to LCPD. On the other hand, there is little information on laboratory studies that could facilitate the diagnosis and treatment of LCPD. METHODS: Blood and plasma samples were tested from 25 patients with LCPD and 50 healthy controls, matched by sex and age. Cellular markers were evaluated through complete blood count, as well as coagulation times, coagulation factors activity, antithrombotic proteins, and homocysteine concentration. RESULTS: After assessing activity value frequencies in each group, the results showed more significant activity in some of the biological risk markers of thrombophilia, presenting a substantial difference in prothrombin time↘, FV↗, FVIII↗, FIX↗, and Hcy↗. These values imply that there may be hypercoagulable states in patients, which can cause thrombotic events. CONCLUSIONS: Diminished prothrombin time and increase in FV activity, FVIII, FIX, and Hcy concentration support the hypothesis that microthrombi formation in small-caliber vessels could be causing avascularity and femoral necrosis, which are traits of LCPD. In addition, based on our results, we believe that the laboratory studies carried out are very useful in the diagnosis and treatment of LCPD.
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spelling pubmed-98692152023-01-24 Prothrombin Time and Coagulation Factor IX as Hemostatic Risk Markers for Legg– Calvé–Perthes Disease Hernández-Zamora, Edgar Rodríguez-Olivas, Armando Odiseo Rosales-Cruz, Erika Galicia-Alvarado, Marlene Alejandra Zavala-Hernández, Cesar Reyes-Maldonado, Elba Clin Appl Thromb Hemost Original Manuscript BACKGROUND: Legg–Calvé–Perthes disease (LCPD) is a pediatric disorder that occurs due to the avascular necrosis of the femoral head and affects the range of motion of the hip in various degrees. Its etiology is still unknown, although it has been associated with coagulation abnormalities, however, the lack of reproducibility in the results in various studies has created a controversy as to whether hemostasis disorders are related to LCPD. On the other hand, there is little information on laboratory studies that could facilitate the diagnosis and treatment of LCPD. METHODS: Blood and plasma samples were tested from 25 patients with LCPD and 50 healthy controls, matched by sex and age. Cellular markers were evaluated through complete blood count, as well as coagulation times, coagulation factors activity, antithrombotic proteins, and homocysteine concentration. RESULTS: After assessing activity value frequencies in each group, the results showed more significant activity in some of the biological risk markers of thrombophilia, presenting a substantial difference in prothrombin time↘, FV↗, FVIII↗, FIX↗, and Hcy↗. These values imply that there may be hypercoagulable states in patients, which can cause thrombotic events. CONCLUSIONS: Diminished prothrombin time and increase in FV activity, FVIII, FIX, and Hcy concentration support the hypothesis that microthrombi formation in small-caliber vessels could be causing avascularity and femoral necrosis, which are traits of LCPD. In addition, based on our results, we believe that the laboratory studies carried out are very useful in the diagnosis and treatment of LCPD. SAGE Publications 2023-01-17 /pmc/articles/PMC9869215/ /pubmed/36650707 http://dx.doi.org/10.1177/10760296221151166 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Manuscript
Hernández-Zamora, Edgar
Rodríguez-Olivas, Armando Odiseo
Rosales-Cruz, Erika
Galicia-Alvarado, Marlene Alejandra
Zavala-Hernández, Cesar
Reyes-Maldonado, Elba
Prothrombin Time and Coagulation Factor IX as Hemostatic Risk Markers for Legg– Calvé–Perthes Disease
title Prothrombin Time and Coagulation Factor IX as Hemostatic Risk Markers for Legg– Calvé–Perthes Disease
title_full Prothrombin Time and Coagulation Factor IX as Hemostatic Risk Markers for Legg– Calvé–Perthes Disease
title_fullStr Prothrombin Time and Coagulation Factor IX as Hemostatic Risk Markers for Legg– Calvé–Perthes Disease
title_full_unstemmed Prothrombin Time and Coagulation Factor IX as Hemostatic Risk Markers for Legg– Calvé–Perthes Disease
title_short Prothrombin Time and Coagulation Factor IX as Hemostatic Risk Markers for Legg– Calvé–Perthes Disease
title_sort prothrombin time and coagulation factor ix as hemostatic risk markers for legg– calvé–perthes disease
topic Original Manuscript
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9869215/
https://www.ncbi.nlm.nih.gov/pubmed/36650707
http://dx.doi.org/10.1177/10760296221151166
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