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Gut-on-a-chip for disease models
The intestinal tract is a vital organ responsible for digestion and absorption in the human body and plays an essential role in pathogen invasion. Compared with other traditional models, gut-on-a-chip has many unique advantages, and thereby, it can be considered as a novel model for studying intesti...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9869227/ https://www.ncbi.nlm.nih.gov/pubmed/36699635 http://dx.doi.org/10.1177/20417314221149882 |
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author | Xian, Changxiu Zhang, Jiaxin Zhao, Suqing Li, Xiang-Guang |
author_facet | Xian, Changxiu Zhang, Jiaxin Zhao, Suqing Li, Xiang-Guang |
author_sort | Xian, Changxiu |
collection | PubMed |
description | The intestinal tract is a vital organ responsible for digestion and absorption in the human body and plays an essential role in pathogen invasion. Compared with other traditional models, gut-on-a-chip has many unique advantages, and thereby, it can be considered as a novel model for studying intestinal functions and diseases. Based on the chip design, we can replicate the in vivo microenvironment of the intestine and study the effects of individual variables on the experiment. In recent years, it has been used to study several diseases. To better mimic the intestinal microenvironment, the structure and function of gut-on-a-chip are constantly optimised and improved. Owing to the complexity of the disease mechanism, gut-on-a-chip can be used in conjunction with other organ chips. In this review, we summarise the human intestinal structure and function as well as the development and improvement of gut-on-a-chip. Finally, we present and discuss gut-on-a-chip applications in inflammatory bowel disease (IBD), viral infections and phenylketonuria. Further improvement of the simulation and high throughput of gut-on-a-chip and realisation of personalised treatments are the problems that should be solved for gut-on-a-chip as a disease model. |
format | Online Article Text |
id | pubmed-9869227 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-98692272023-01-24 Gut-on-a-chip for disease models Xian, Changxiu Zhang, Jiaxin Zhao, Suqing Li, Xiang-Guang J Tissue Eng Review The intestinal tract is a vital organ responsible for digestion and absorption in the human body and plays an essential role in pathogen invasion. Compared with other traditional models, gut-on-a-chip has many unique advantages, and thereby, it can be considered as a novel model for studying intestinal functions and diseases. Based on the chip design, we can replicate the in vivo microenvironment of the intestine and study the effects of individual variables on the experiment. In recent years, it has been used to study several diseases. To better mimic the intestinal microenvironment, the structure and function of gut-on-a-chip are constantly optimised and improved. Owing to the complexity of the disease mechanism, gut-on-a-chip can be used in conjunction with other organ chips. In this review, we summarise the human intestinal structure and function as well as the development and improvement of gut-on-a-chip. Finally, we present and discuss gut-on-a-chip applications in inflammatory bowel disease (IBD), viral infections and phenylketonuria. Further improvement of the simulation and high throughput of gut-on-a-chip and realisation of personalised treatments are the problems that should be solved for gut-on-a-chip as a disease model. SAGE Publications 2023-01-18 /pmc/articles/PMC9869227/ /pubmed/36699635 http://dx.doi.org/10.1177/20417314221149882 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Review Xian, Changxiu Zhang, Jiaxin Zhao, Suqing Li, Xiang-Guang Gut-on-a-chip for disease models |
title | Gut-on-a-chip for disease models |
title_full | Gut-on-a-chip for disease models |
title_fullStr | Gut-on-a-chip for disease models |
title_full_unstemmed | Gut-on-a-chip for disease models |
title_short | Gut-on-a-chip for disease models |
title_sort | gut-on-a-chip for disease models |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9869227/ https://www.ncbi.nlm.nih.gov/pubmed/36699635 http://dx.doi.org/10.1177/20417314221149882 |
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