Cargando…
The potential use of mesenchymal stem cells-derived exosomes as microRNAs delivery systems in different diseases
MicroRNAs (miRNAs) are a group of small non-coding RNAs that regulate gene expression by targeting mRNA. Moreover, it has been shown that miRNAs expression are changed in various diseases, such as cancers, autoimmune disease, infectious diseases, and neurodegenerative Diseases. The suppression of mi...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9869323/ https://www.ncbi.nlm.nih.gov/pubmed/36690996 http://dx.doi.org/10.1186/s12964-022-01017-9 |
_version_ | 1784876747122016256 |
---|---|
author | Oveili, Elham Vafaei, Somayeh Bazavar, Haniyeh Eslami, Yeganeh Mamaghanizadeh, Ehsan Yasamineh, Saman Gholizadeh, Omid |
author_facet | Oveili, Elham Vafaei, Somayeh Bazavar, Haniyeh Eslami, Yeganeh Mamaghanizadeh, Ehsan Yasamineh, Saman Gholizadeh, Omid |
author_sort | Oveili, Elham |
collection | PubMed |
description | MicroRNAs (miRNAs) are a group of small non-coding RNAs that regulate gene expression by targeting mRNA. Moreover, it has been shown that miRNAs expression are changed in various diseases, such as cancers, autoimmune disease, infectious diseases, and neurodegenerative Diseases. The suppression of miRNA function can be easily attained by utilizing of anti-miRNAs. In contrast, an enhancement in miRNA function can be achieved through the utilization of modified miRNA mimetics. The discovery of appropriate miRNA carriers in the body has become an interesting subject for investigators. Exosomes (EXOs) therapeutic efficiency and safety for transferring different cellular biological components to the recipient cell have attracted significant attention for their capability as miRNA carriers. Mesenchymal stem cells (MSCs) are recognized to generate a wide range of EXOs (MSC-EXOs), showing that MSCs may be effective for EXO generation in a clinically appropriate measure as compared to other cell origins. MSC-EXOs have been widely investigated because of their immune attributes, tumor-homing attributes, and flexible characteristics. In this article, we summarized the features of miRNAs and MSC-EXOs, including production, purification, and miRNA loading methods of MSC-EXOs, and the modification of MSC-EXOs for targeted miRNA delivery in various diseases. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12964-022-01017-9. |
format | Online Article Text |
id | pubmed-9869323 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-98693232023-01-23 The potential use of mesenchymal stem cells-derived exosomes as microRNAs delivery systems in different diseases Oveili, Elham Vafaei, Somayeh Bazavar, Haniyeh Eslami, Yeganeh Mamaghanizadeh, Ehsan Yasamineh, Saman Gholizadeh, Omid Cell Commun Signal Review MicroRNAs (miRNAs) are a group of small non-coding RNAs that regulate gene expression by targeting mRNA. Moreover, it has been shown that miRNAs expression are changed in various diseases, such as cancers, autoimmune disease, infectious diseases, and neurodegenerative Diseases. The suppression of miRNA function can be easily attained by utilizing of anti-miRNAs. In contrast, an enhancement in miRNA function can be achieved through the utilization of modified miRNA mimetics. The discovery of appropriate miRNA carriers in the body has become an interesting subject for investigators. Exosomes (EXOs) therapeutic efficiency and safety for transferring different cellular biological components to the recipient cell have attracted significant attention for their capability as miRNA carriers. Mesenchymal stem cells (MSCs) are recognized to generate a wide range of EXOs (MSC-EXOs), showing that MSCs may be effective for EXO generation in a clinically appropriate measure as compared to other cell origins. MSC-EXOs have been widely investigated because of their immune attributes, tumor-homing attributes, and flexible characteristics. In this article, we summarized the features of miRNAs and MSC-EXOs, including production, purification, and miRNA loading methods of MSC-EXOs, and the modification of MSC-EXOs for targeted miRNA delivery in various diseases. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12964-022-01017-9. BioMed Central 2023-01-23 /pmc/articles/PMC9869323/ /pubmed/36690996 http://dx.doi.org/10.1186/s12964-022-01017-9 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Oveili, Elham Vafaei, Somayeh Bazavar, Haniyeh Eslami, Yeganeh Mamaghanizadeh, Ehsan Yasamineh, Saman Gholizadeh, Omid The potential use of mesenchymal stem cells-derived exosomes as microRNAs delivery systems in different diseases |
title | The potential use of mesenchymal stem cells-derived exosomes as microRNAs delivery systems in different diseases |
title_full | The potential use of mesenchymal stem cells-derived exosomes as microRNAs delivery systems in different diseases |
title_fullStr | The potential use of mesenchymal stem cells-derived exosomes as microRNAs delivery systems in different diseases |
title_full_unstemmed | The potential use of mesenchymal stem cells-derived exosomes as microRNAs delivery systems in different diseases |
title_short | The potential use of mesenchymal stem cells-derived exosomes as microRNAs delivery systems in different diseases |
title_sort | potential use of mesenchymal stem cells-derived exosomes as micrornas delivery systems in different diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9869323/ https://www.ncbi.nlm.nih.gov/pubmed/36690996 http://dx.doi.org/10.1186/s12964-022-01017-9 |
work_keys_str_mv | AT oveilielham thepotentialuseofmesenchymalstemcellsderivedexosomesasmicrornasdeliverysystemsindifferentdiseases AT vafaeisomayeh thepotentialuseofmesenchymalstemcellsderivedexosomesasmicrornasdeliverysystemsindifferentdiseases AT bazavarhaniyeh thepotentialuseofmesenchymalstemcellsderivedexosomesasmicrornasdeliverysystemsindifferentdiseases AT eslamiyeganeh thepotentialuseofmesenchymalstemcellsderivedexosomesasmicrornasdeliverysystemsindifferentdiseases AT mamaghanizadehehsan thepotentialuseofmesenchymalstemcellsderivedexosomesasmicrornasdeliverysystemsindifferentdiseases AT yasaminehsaman thepotentialuseofmesenchymalstemcellsderivedexosomesasmicrornasdeliverysystemsindifferentdiseases AT gholizadehomid thepotentialuseofmesenchymalstemcellsderivedexosomesasmicrornasdeliverysystemsindifferentdiseases AT oveilielham potentialuseofmesenchymalstemcellsderivedexosomesasmicrornasdeliverysystemsindifferentdiseases AT vafaeisomayeh potentialuseofmesenchymalstemcellsderivedexosomesasmicrornasdeliverysystemsindifferentdiseases AT bazavarhaniyeh potentialuseofmesenchymalstemcellsderivedexosomesasmicrornasdeliverysystemsindifferentdiseases AT eslamiyeganeh potentialuseofmesenchymalstemcellsderivedexosomesasmicrornasdeliverysystemsindifferentdiseases AT mamaghanizadehehsan potentialuseofmesenchymalstemcellsderivedexosomesasmicrornasdeliverysystemsindifferentdiseases AT yasaminehsaman potentialuseofmesenchymalstemcellsderivedexosomesasmicrornasdeliverysystemsindifferentdiseases AT gholizadehomid potentialuseofmesenchymalstemcellsderivedexosomesasmicrornasdeliverysystemsindifferentdiseases |