Parkin coregulates glutathione metabolism in adult mammalian brain

We recently discovered that the expression of PRKN, a young-onset Parkinson disease-linked gene, confers redox homeostasis. To further examine the protective effects of parkin in an oxidative stress model, we first combined the loss of prkn with Sod2 haploinsufficiency in mice. Although adult prkn(−...

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Detalles Bibliográficos
Autores principales: El Kodsi, Daniel N., Tokarew, Jacqueline M., Sengupta, Rajib, Lengacher, Nathalie A., Chatterji, Ajanta, Nguyen, Angela P., Boston, Heather, Jiang, Qiubo, Palmberg, Carina, Pileggi, Chantal, Holterman, Chet E., Shutinoski, Bojan, Li, Juan, Fehr, Travis K., LaVoie, Matthew J., Ratan, Rajiv R., Shaw, Gary S., Takanashi, Masashi, Hattori, Nobutaka, Kennedy, Christopher R., Harper, Mary-Ellen, Holmgren, Arne, Tomlinson, Julianna J., Schlossmacher, Michael G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9869535/
https://www.ncbi.nlm.nih.gov/pubmed/36691076
http://dx.doi.org/10.1186/s40478-022-01488-4

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