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DNA methylation signatures as biomarkers of socioeconomic position

This review article provides a framework for the use of deoxyribonucleic acid (DNA) methylation (DNAm) biomarkers to study the biological embedding of socioeconomic position (SEP) and summarizes the latest developments in the area. It presents the emerging literature showing associations between ind...

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Detalles Bibliográficos
Autores principales: Rajaprakash, Meghna, Dean, Lorraine T, Palmore, Meredith, Johnson, Sara B, Kaufman, Joan, Fallin, Daniele M, Ladd-Acosta, Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9869656/
https://www.ncbi.nlm.nih.gov/pubmed/36694711
http://dx.doi.org/10.1093/eep/dvac027
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author Rajaprakash, Meghna
Dean, Lorraine T
Palmore, Meredith
Johnson, Sara B
Kaufman, Joan
Fallin, Daniele M
Ladd-Acosta, Christine
author_facet Rajaprakash, Meghna
Dean, Lorraine T
Palmore, Meredith
Johnson, Sara B
Kaufman, Joan
Fallin, Daniele M
Ladd-Acosta, Christine
author_sort Rajaprakash, Meghna
collection PubMed
description This review article provides a framework for the use of deoxyribonucleic acid (DNA) methylation (DNAm) biomarkers to study the biological embedding of socioeconomic position (SEP) and summarizes the latest developments in the area. It presents the emerging literature showing associations between individual- and neighborhood-level SEP exposures and DNAm across the life course. In contrast to questionnaire-based methods of assessing SEP, we suggest that DNAm biomarkers may offer an accessible metric to study questions about SEP and health outcomes, acting as a personal dosimeter of exposure. However, further work remains in standardizing SEP measures across studies and evaluating consistency across domains, tissue types, and time periods. Meta-analyses of epigenetic associations with SEP are offered as one approach to confirm the replication of DNAm loci across studies. The development of DNAm biomarkers of SEP would provide a method for examining its impact on health outcomes in a more robust way, increasing the rigor of epidemiological studies.
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spelling pubmed-98696562023-01-23 DNA methylation signatures as biomarkers of socioeconomic position Rajaprakash, Meghna Dean, Lorraine T Palmore, Meredith Johnson, Sara B Kaufman, Joan Fallin, Daniele M Ladd-Acosta, Christine Environ Epigenet Review Article This review article provides a framework for the use of deoxyribonucleic acid (DNA) methylation (DNAm) biomarkers to study the biological embedding of socioeconomic position (SEP) and summarizes the latest developments in the area. It presents the emerging literature showing associations between individual- and neighborhood-level SEP exposures and DNAm across the life course. In contrast to questionnaire-based methods of assessing SEP, we suggest that DNAm biomarkers may offer an accessible metric to study questions about SEP and health outcomes, acting as a personal dosimeter of exposure. However, further work remains in standardizing SEP measures across studies and evaluating consistency across domains, tissue types, and time periods. Meta-analyses of epigenetic associations with SEP are offered as one approach to confirm the replication of DNAm loci across studies. The development of DNAm biomarkers of SEP would provide a method for examining its impact on health outcomes in a more robust way, increasing the rigor of epidemiological studies. Oxford University Press 2022-12-14 /pmc/articles/PMC9869656/ /pubmed/36694711 http://dx.doi.org/10.1093/eep/dvac027 Text en © The Author(s) 2023. Published by Oxford University Press. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Rajaprakash, Meghna
Dean, Lorraine T
Palmore, Meredith
Johnson, Sara B
Kaufman, Joan
Fallin, Daniele M
Ladd-Acosta, Christine
DNA methylation signatures as biomarkers of socioeconomic position
title DNA methylation signatures as biomarkers of socioeconomic position
title_full DNA methylation signatures as biomarkers of socioeconomic position
title_fullStr DNA methylation signatures as biomarkers of socioeconomic position
title_full_unstemmed DNA methylation signatures as biomarkers of socioeconomic position
title_short DNA methylation signatures as biomarkers of socioeconomic position
title_sort dna methylation signatures as biomarkers of socioeconomic position
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9869656/
https://www.ncbi.nlm.nih.gov/pubmed/36694711
http://dx.doi.org/10.1093/eep/dvac027
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