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Glucose-insulin-potassium alleviates uterine cramping pain following cesarean delivery: A randomized, controlled trial

OBJECTIVES: To explore the effect of glucose-insulin-potassium (GIK) therapy on uterine cramping pain (UCP) following cesarean delivery (CD). DESIGN: Single-center, randomized controlled study. SETTING: Second Affiliated Hospital of Army Medical University, Chongqing, China. PARTICIPANTS: A total of...

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Autores principales: Yang, Guiying, Cui, Yu, Bao, Xiaohang, Wu, Zhuoxi, Chen, Qin, Chen, Feng, Liu, Wenjun, Wang, Mingming, Luo, Li, Li, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9869677/
https://www.ncbi.nlm.nih.gov/pubmed/36700014
http://dx.doi.org/10.3389/fsurg.2022.1068993
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author Yang, Guiying
Cui, Yu
Bao, Xiaohang
Wu, Zhuoxi
Chen, Qin
Chen, Feng
Liu, Wenjun
Wang, Mingming
Luo, Li
Li, Hong
author_facet Yang, Guiying
Cui, Yu
Bao, Xiaohang
Wu, Zhuoxi
Chen, Qin
Chen, Feng
Liu, Wenjun
Wang, Mingming
Luo, Li
Li, Hong
author_sort Yang, Guiying
collection PubMed
description OBJECTIVES: To explore the effect of glucose-insulin-potassium (GIK) therapy on uterine cramping pain (UCP) following cesarean delivery (CD). DESIGN: Single-center, randomized controlled study. SETTING: Second Affiliated Hospital of Army Medical University, Chongqing, China. PARTICIPANTS: A total of 140 women, aged 20–40 years, who underwent CD with a transverse incision were randomly assigned to the GIK (P) or control (C) groups in a 1:1 ratio. INTERVENTIONS: GIK was intravenously administered to patients in Group P. Patients in Group C received normal saline (NS). After umbilical cord clamping, oxytocin was administered intravenously. The same GIK and NS regimens were administered on postoperative days 1 and 2, followed by oxytocin 10 min later. PRIMARY AND SECONDARY OUTCOME MEASURES: Following oxytocin administration, UCP was assessed using the visual analog scale (VAS), and the maximum VAS score (primary outcome) was recorded. RESULTS: Patients in Group P had significantly lower maximum VAS scores than those in Group C on postoperative days 1 (38.4 ± 21.1 vs. 52.3 ± 20.8, p < 0.001) and 2 (10 [0,30] vs. 30.5 [8.75,50], p < 0.001). Group P patients also had shorter pain duration on postoperative day 1 (39.6 ± 19.5 min vs. 50.6 ± 18.2 min, p = 0.001). Group P patients had a lower incidence of inadequate analgesia of UCP than Group C on days 1 (45.5% vs. 74.2%, p < 0.001) and 2 (10.6% vs. 47.0%, p < 0.001); the RRs for experiencing inadequate analgesia for UCP postpartum in Group P patients was 0.612 (95% CI: 0.454–0.826, p < 0.001) on day 1 and 0.226 (95% CI: 0.107–0.476, p < 0.001) on day 2. The absolute risk reduction (ARR) was 28.7%; thus number needed to treat (NNT) was 3 after rounding up. A subgroup analysis demonstrated that Group P patients undergoing repeat CD had lower maximum VAS scores for UCP on both postoperative days 1 and 2. CONCLUSION: Our findings suggest that GIK can relieve UCP and shorten its duration. Our results provide information to facilitate the development of novel approaches for managing UCP. Clinical Trial Registration: This study was approved by the Medical Ethics Committee of Second Affiliated Hospital of Army Medical University (2020-109-01, 19/11/2020) and registered in the Chinese Clinical Trial Registry (http://www.chictr.org.cn, ChiCTR2100041607,01/01/2021).
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spelling pubmed-98696772023-01-24 Glucose-insulin-potassium alleviates uterine cramping pain following cesarean delivery: A randomized, controlled trial Yang, Guiying Cui, Yu Bao, Xiaohang Wu, Zhuoxi Chen, Qin Chen, Feng Liu, Wenjun Wang, Mingming Luo, Li Li, Hong Front Surg Surgery OBJECTIVES: To explore the effect of glucose-insulin-potassium (GIK) therapy on uterine cramping pain (UCP) following cesarean delivery (CD). DESIGN: Single-center, randomized controlled study. SETTING: Second Affiliated Hospital of Army Medical University, Chongqing, China. PARTICIPANTS: A total of 140 women, aged 20–40 years, who underwent CD with a transverse incision were randomly assigned to the GIK (P) or control (C) groups in a 1:1 ratio. INTERVENTIONS: GIK was intravenously administered to patients in Group P. Patients in Group C received normal saline (NS). After umbilical cord clamping, oxytocin was administered intravenously. The same GIK and NS regimens were administered on postoperative days 1 and 2, followed by oxytocin 10 min later. PRIMARY AND SECONDARY OUTCOME MEASURES: Following oxytocin administration, UCP was assessed using the visual analog scale (VAS), and the maximum VAS score (primary outcome) was recorded. RESULTS: Patients in Group P had significantly lower maximum VAS scores than those in Group C on postoperative days 1 (38.4 ± 21.1 vs. 52.3 ± 20.8, p < 0.001) and 2 (10 [0,30] vs. 30.5 [8.75,50], p < 0.001). Group P patients also had shorter pain duration on postoperative day 1 (39.6 ± 19.5 min vs. 50.6 ± 18.2 min, p = 0.001). Group P patients had a lower incidence of inadequate analgesia of UCP than Group C on days 1 (45.5% vs. 74.2%, p < 0.001) and 2 (10.6% vs. 47.0%, p < 0.001); the RRs for experiencing inadequate analgesia for UCP postpartum in Group P patients was 0.612 (95% CI: 0.454–0.826, p < 0.001) on day 1 and 0.226 (95% CI: 0.107–0.476, p < 0.001) on day 2. The absolute risk reduction (ARR) was 28.7%; thus number needed to treat (NNT) was 3 after rounding up. A subgroup analysis demonstrated that Group P patients undergoing repeat CD had lower maximum VAS scores for UCP on both postoperative days 1 and 2. CONCLUSION: Our findings suggest that GIK can relieve UCP and shorten its duration. Our results provide information to facilitate the development of novel approaches for managing UCP. Clinical Trial Registration: This study was approved by the Medical Ethics Committee of Second Affiliated Hospital of Army Medical University (2020-109-01, 19/11/2020) and registered in the Chinese Clinical Trial Registry (http://www.chictr.org.cn, ChiCTR2100041607,01/01/2021). Frontiers Media S.A. 2023-01-09 /pmc/articles/PMC9869677/ /pubmed/36700014 http://dx.doi.org/10.3389/fsurg.2022.1068993 Text en © 2023 Yang, Cui, Bao, Wu, Chen, Chen, Liu, Wang, Luo and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Surgery
Yang, Guiying
Cui, Yu
Bao, Xiaohang
Wu, Zhuoxi
Chen, Qin
Chen, Feng
Liu, Wenjun
Wang, Mingming
Luo, Li
Li, Hong
Glucose-insulin-potassium alleviates uterine cramping pain following cesarean delivery: A randomized, controlled trial
title Glucose-insulin-potassium alleviates uterine cramping pain following cesarean delivery: A randomized, controlled trial
title_full Glucose-insulin-potassium alleviates uterine cramping pain following cesarean delivery: A randomized, controlled trial
title_fullStr Glucose-insulin-potassium alleviates uterine cramping pain following cesarean delivery: A randomized, controlled trial
title_full_unstemmed Glucose-insulin-potassium alleviates uterine cramping pain following cesarean delivery: A randomized, controlled trial
title_short Glucose-insulin-potassium alleviates uterine cramping pain following cesarean delivery: A randomized, controlled trial
title_sort glucose-insulin-potassium alleviates uterine cramping pain following cesarean delivery: a randomized, controlled trial
topic Surgery
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9869677/
https://www.ncbi.nlm.nih.gov/pubmed/36700014
http://dx.doi.org/10.3389/fsurg.2022.1068993
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