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Primary squamous cell carcinoma of the breast: A case report and review of the literature

Primary squamous cell carcinoma (PSCC) of the breast, as a rare metaplastic breast cancer, currently has limited clinical data on its biological behavior, treatment and prognosis. At present, the optimal treatment of this tumor is still controversial. We reported a case of a 56-year-old woman with a...

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Autores principales: Wu, Yaping, Chen, Zhiying, Li, Wei, Wang, Fengguang, Zhang, Yongchun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9869869/
https://www.ncbi.nlm.nih.gov/pubmed/36698422
http://dx.doi.org/10.3389/fonc.2022.1033084
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author Wu, Yaping
Chen, Zhiying
Li, Wei
Wang, Fengguang
Zhang, Yongchun
author_facet Wu, Yaping
Chen, Zhiying
Li, Wei
Wang, Fengguang
Zhang, Yongchun
author_sort Wu, Yaping
collection PubMed
description Primary squamous cell carcinoma (PSCC) of the breast, as a rare metaplastic breast cancer, currently has limited clinical data on its biological behavior, treatment and prognosis. At present, the optimal treatment of this tumor is still controversial. We reported a case of a 56-year-old woman with a mass on the right breast. She underwent a modified radical mastectomy and lymph node biopsy, which revealed that the tumor was a metaplastic squamous cell carcinoma with axillary lymph node metastasis, followed by traditional adjuvant chemotherapy and radiotherapy. The patient re-examined by PET/CT after two years in May 2017 and found a recurrence in the right chest wall, so resection of the recurring lesion was resected, then she was given postoperative adjuvant radiotherapy and chemotherapy. In August 2019, the patient re-examined by PET/CT, and there were pulmonary and mediastinal lymph node metastases. After 4 cycles of albumin paclitaxel plus cisplatin chemotherapy combined with nivolumab immunotherapy, the patient achieved complete response (CR), and then switched to nivolumab immune maintenance therapy. So far, no obvious metastasis has been seen. We believe that surgical treatment is necessary for PSCC of the breast;paclitaxel and cisplatin chemotherapy regimens and adjuvant radiotherapy are effective, but it may be resistant to radiotherapy; and immunotherapy may prolong the survival of patients with PSCC of the breast.
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spelling pubmed-98698692023-01-24 Primary squamous cell carcinoma of the breast: A case report and review of the literature Wu, Yaping Chen, Zhiying Li, Wei Wang, Fengguang Zhang, Yongchun Front Oncol Oncology Primary squamous cell carcinoma (PSCC) of the breast, as a rare metaplastic breast cancer, currently has limited clinical data on its biological behavior, treatment and prognosis. At present, the optimal treatment of this tumor is still controversial. We reported a case of a 56-year-old woman with a mass on the right breast. She underwent a modified radical mastectomy and lymph node biopsy, which revealed that the tumor was a metaplastic squamous cell carcinoma with axillary lymph node metastasis, followed by traditional adjuvant chemotherapy and radiotherapy. The patient re-examined by PET/CT after two years in May 2017 and found a recurrence in the right chest wall, so resection of the recurring lesion was resected, then she was given postoperative adjuvant radiotherapy and chemotherapy. In August 2019, the patient re-examined by PET/CT, and there were pulmonary and mediastinal lymph node metastases. After 4 cycles of albumin paclitaxel plus cisplatin chemotherapy combined with nivolumab immunotherapy, the patient achieved complete response (CR), and then switched to nivolumab immune maintenance therapy. So far, no obvious metastasis has been seen. We believe that surgical treatment is necessary for PSCC of the breast;paclitaxel and cisplatin chemotherapy regimens and adjuvant radiotherapy are effective, but it may be resistant to radiotherapy; and immunotherapy may prolong the survival of patients with PSCC of the breast. Frontiers Media S.A. 2023-01-06 /pmc/articles/PMC9869869/ /pubmed/36698422 http://dx.doi.org/10.3389/fonc.2022.1033084 Text en Copyright © 2023 Wu, Chen, Li, Wang and Zhang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Wu, Yaping
Chen, Zhiying
Li, Wei
Wang, Fengguang
Zhang, Yongchun
Primary squamous cell carcinoma of the breast: A case report and review of the literature
title Primary squamous cell carcinoma of the breast: A case report and review of the literature
title_full Primary squamous cell carcinoma of the breast: A case report and review of the literature
title_fullStr Primary squamous cell carcinoma of the breast: A case report and review of the literature
title_full_unstemmed Primary squamous cell carcinoma of the breast: A case report and review of the literature
title_short Primary squamous cell carcinoma of the breast: A case report and review of the literature
title_sort primary squamous cell carcinoma of the breast: a case report and review of the literature
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9869869/
https://www.ncbi.nlm.nih.gov/pubmed/36698422
http://dx.doi.org/10.3389/fonc.2022.1033084
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