TNF receptor–related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase–mediated hepatocyte transdifferentiation

BACKGROUND AND AIMS: Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets. APPROACH AND RESULTS: We performed a Sleeping Beaut...

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Detalles Bibliográficos
Autores principales: Shiode, Yuto, Kodama, Takahiro, Shigeno, Satoshi, Murai, Kazuhiro, Tanaka, Satoshi, Newberg, Justin Y., Kondo, Jumpei, Kobayashi, Shogo, Yamada, Ryoko, Hikita, Hayato, Sakamori, Ryotaro, Suemizu, Hiroshi, Tatsumi, Tomohide, Eguchi, Hidetoshi, Jenkins, Nancy A., Copeland, Neal G., Takehara, Tetsuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Original Articles: Liver Cancer
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9869956/
https://www.ncbi.nlm.nih.gov/pubmed/34995376
http://dx.doi.org/10.1002/hep.32317

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