Muscle weakness precedes atrophy during cancer cachexia and is linked to muscle-specific mitochondrial stress

Muscle weakness and wasting are defining features of cancer-induced cachexia. Mitochondrial stress occurs before atrophy in certain muscles, but the possibility of heterogeneous responses between muscles and across time remains unclear. Using mice inoculated with Colon-26 cancer, we demonstrate that...

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Detalles Bibliográficos
Autores principales: Delfinis, Luca J., Bellissimo, Catherine A., Gandhi, Shivam, DiBenedetto, Sara N., Garibotti, Madison C., Thuhan, Arshdeep K., Tsitkanou, Stavroula, Rosa-Caldwell, Megan E., Rahman, Fasih A., Cheng, Arthur J., Wiggs, Michael P., Schlattner, Uwe, Quadrilatero, Joe, Greene, Nicholas P., Perry, Christopher G.R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9869968/
https://www.ncbi.nlm.nih.gov/pubmed/36346680
http://dx.doi.org/10.1172/jci.insight.155147

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9869968/
https://www.ncbi.nlm.nih.gov/pubmed/36346680
http://dx.doi.org/10.1172/jci.insight.155147

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