ATR represents a therapeutic vulnerability in clear cell renal cell carcinoma

Metastatic clear cell renal cell carcinomas (ccRCCs) are resistant to DNA-damaging chemotherapies, limiting therapeutic options for patients whose tumors are resistant to tyrosine kinase inhibitors and/or immune checkpoint therapies. Here we show that mouse and human ccRCCs were frequently character...

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Detalles Bibliográficos
Autores principales: Seidel, Philipp, Rubarth, Anne, Zodel, Kyra, Peighambari, Asin, Neumann, Felix, Federkiel, Yannick, Huang, Hsin, Hoefflin, Rouven, Adlesic, Mojca, Witt, Christian, Hoffmann, David J., Metzger, Patrick, Lindemann, Ralph K., Zenke, Frank T., Schell, Christoph, Boerries, Melanie, von Elverfeldt, Dominik, Reichardt, Wilfried, Follo, Marie, Albers, Joachim, Frew, Ian J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9869969/
https://www.ncbi.nlm.nih.gov/pubmed/36413415
http://dx.doi.org/10.1172/jci.insight.156087

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