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Impaired Treg-DC interactions contribute to autoimmunity in leukocyte adhesion deficiency type 1

Leukocyte adhesion deficiency type 1 (LAD-1) is a rare disease resulting from mutations in the gene encoding for the common β-chain of the β(2)-integrin family (CD18). The most prominent clinical symptoms are profound leukocytosis and high susceptibility to infections. Patients with LAD-1 are prone...

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Detalles Bibliográficos
Autores principales:	Klaus, Tanja, Wilson, Alicia S., Vicari, Elisabeth, Hadaschik, Eva, Klein, Matthias, Helbich, Sara Salome Clara, Kamenjarin, Nadine, Hodapp, Katrin, Schunke, Jenny, Haist, Maximilian, Butsch, Florian, Probst, Hans Christian, Enk, Alexander H., Mahnke, Karsten, Waisman, Ari, Bednarczyk, Monika, Bros, Matthias, Bopp, Tobias, Grabbe, Stephan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9869970/ https://www.ncbi.nlm.nih.gov/pubmed/36346673 http://dx.doi.org/10.1172/jci.insight.162580

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