Human JAK1 gain of function causes dysregulated myelopoeisis and severe allergic inflammation

Primary atopic disorders are a group of inborn errors of immunity that skew the immune system toward severe allergic disease. Defining the biology underlying these extreme monogenic phenotypes reveals shared mechanisms underlying common polygenic allergic disease and identifies potential drug target...

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Detalles Bibliográficos
Autores principales: Biggs, Catherine M., Cordeiro-Santanach, Anna, Prykhozhij, Sergey V., Deveau, Adam P., Lin, Yi, Del Bel, Kate L., Orben, Felix, Ragotte, Robert J., Saferali, Aabida, Mostafavi, Sara, Dinh, Louie, Dai, Darlene, Weinacht, Katja G., Dobbs, Kerry, Ott de Bruin, Lisa, Sharma, Mehul, Tsai, Kevin, Priatel, John J., Schreiber, Richard A., Rozmus, Jacob, Hosking, Martin C.K., Shopsowitz, Kevin E., McKinnon, Margaret L., Vercauteren, Suzanne, Seear, Michael, Notarangelo, Luigi D., Lynn, Francis C., Berman, Jason N., Turvey, Stuart E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9869972/
https://www.ncbi.nlm.nih.gov/pubmed/36546480
http://dx.doi.org/10.1172/jci.insight.150849

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