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Low c-Kit expression identifies primitive, therapy-resistant CML stem cells

Despite the efficacy of tyrosine kinase inhibitors (TKIs) in chronic myeloid leukemia (CML), malignant long-term hematopoietic stem cells (LT-HSCs) persist as a source of relapse. However, LT-HSCs are heterogenous and the most primitive, drug-resistant LT-HSC subpopulations are not well characterize...

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Detalles Bibliográficos
Autores principales:	Shah, Mansi, Kumar, Harish, Qiu, Shaowei, Li, Hui, Harris, Mason, He, Jianbo, Abraham, Ajay, Crossman, David K., Paterson, Andrew, Welner, Robert S., Bhatia, Ravi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9870079/ https://www.ncbi.nlm.nih.gov/pubmed/36413413 http://dx.doi.org/10.1172/jci.insight.157421

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