Culture impact on the transcriptomic programs of primary and iPSC-derived human alveolar type 2 cells

Dysfunction of alveolar epithelial type 2 cells (AEC2s), the facultative progenitors of lung alveoli, is implicated in pulmonary disease pathogenesis, highlighting the importance of human in vitro models. However, AEC2-like cells in culture have yet to be directly compared to their in vivo counterpa...

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Detalles Bibliográficos
Autores principales: Alysandratos, Konstantinos-Dionysios, Garcia-de-Alba, Carolina, Yao, Changfu, Pessina, Patrizia, Huang, Jessie, Villacorta-Martin, Carlos, Hix, Olivia T., Minakin, Kasey, Burgess, Claire L., Bawa, Pushpinder, Murthy, Aditi, Konda, Bindu, Beers, Michael F., Stripp, Barry R., Kim, Carla F., Kotton, Darrell N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9870086/
https://www.ncbi.nlm.nih.gov/pubmed/36454643
http://dx.doi.org/10.1172/jci.insight.158937

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