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Atp7b-dependent choroid plexus dysfunction causes transient copper deficit and metabolic changes in the developing mouse brain

Copper (Cu) has a multifaceted role in brain development, function, and metabolism. Two homologous Cu transporters, Atp7a (Menkes disease protein) and Atp7b (Wilson disease protein), maintain Cu homeostasis in the tissue. Atp7a mediates Cu entry into the brain and activates Cu-dependent enzymes, whe...

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Detalles Bibliográficos
Autores principales:	Washington-Hughes, Clorissa L., Roy, Shubhrajit, Seneviratne, Herana Kamal, Karuppagounder, Senthilkumar S., Morel, Yulemni, Jones, Jace W., Zak, Alex, Xiao, Tong, Boronina, Tatiana N., Cole, Robert N., Bumpus, Namandjé N., Chang, Christopher J., Dawson, Ted M., Lutsenko, Svetlana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9870141/ https://www.ncbi.nlm.nih.gov/pubmed/36626371 http://dx.doi.org/10.1371/journal.pgen.1010558

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