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Conformational diversity in purified prions produced in vitro

Prion diseases are caused by misfolding of either wild-type or mutant forms of the prion protein (PrP) into self-propagating, pathogenic conformers, collectively termed PrP(Sc). Both wild-type and mutant PrP(Sc) molecules exhibit conformational diversity in vivo, but purified prions generated by the...

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Detalles Bibliográficos
Autores principales:	Walsh, Daniel J., Schwind, Abigail M., Noble, Geoffrey P., Supattapone, Surachai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9870145/ https://www.ncbi.nlm.nih.gov/pubmed/36626391 http://dx.doi.org/10.1371/journal.ppat.1011083

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