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Structure and neutralization mechanism of a human antibody targeting a complex Epitope on Zika virus

We currently have an incomplete understanding of why only a fraction of human antibodies that bind to flaviviruses block infection of cells. Here we define the footprint of a strongly neutralizing human monoclonal antibody (mAb G9E) with Zika virus (ZIKV) by both X-ray crystallography and cryo-elect...

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Detalles Bibliográficos
Autores principales:	Adams, Cameron, Carbaugh, Derek L., Shu, Bo, Ng, Thiam-Seng, Castillo, Izabella N., Bhowmik, Ryan, Segovia-Chumbez, Bruno, Puhl, Ana C., Graham, Stephen, Diehl, Sean A., Lazear, Helen M., Lok, Shee-mei, de Silva, Aravinda M., Premkumar, Lakshmanane
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9870165/ https://www.ncbi.nlm.nih.gov/pubmed/36626401 http://dx.doi.org/10.1371/journal.ppat.1010814

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