Efficacy and Safety of Trametinib Monotherapy or in Combination With Dabrafenib in Pediatric BRAF V600–Mutant Low-Grade Glioma

BRAF V600 mutations occur in many childhood cancers, including approximately 20% of low-grade gliomas (LGGs). Here, we describe a phase I/II study establishing pediatric dosing and pharmacokinetics of trametinib with or without dabrafenib, as well as efficacy and safety in a disease-specific cohort...

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Detalles Bibliográficos
Autores principales: Bouffet, Eric, Geoerger, Birgit, Moertel, Christopher, Whitlock, James A., Aerts, Isabelle, Hargrave, Darren, Osterloh, Lisa, Tan, Eugene, Choi, Jeea, Russo, Mark, Fox, Elizabeth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2023
Materias:
ORIGINAL REPORTS
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9870224/
https://www.ncbi.nlm.nih.gov/pubmed/36375115
http://dx.doi.org/10.1200/JCO.22.01000

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