Cargando…

Application of a multispecies probiotic reduces gastro-intestinal discomfort and induces microbial changes after colonoscopy

Even after decades of research and pharmaceutical development, cancer is still one of the most common causes of death in the western population and the management of cancer will remain a major challenge of medical research. One of the most common types of cancer is colorectal cancer (CRC). Preventio...

Descripción completa

Detalles Bibliográficos
Autores principales: Labenz, Joachim, Borkenstein, Daniela-Patricia, Heil, Franz Josef, Madisch, Ahmed, Tappe, Ulrich, Schmidt, Harald, Terjung, Birgit, Klymiuk, Ingeborg, Horvath, Angela, Gross, Manfred, Stadlbauer, Vanessa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9870247/
https://www.ncbi.nlm.nih.gov/pubmed/36698396
http://dx.doi.org/10.3389/fonc.2022.1078315
_version_ 1784876934216286208
author Labenz, Joachim
Borkenstein, Daniela-Patricia
Heil, Franz Josef
Madisch, Ahmed
Tappe, Ulrich
Schmidt, Harald
Terjung, Birgit
Klymiuk, Ingeborg
Horvath, Angela
Gross, Manfred
Stadlbauer, Vanessa
author_facet Labenz, Joachim
Borkenstein, Daniela-Patricia
Heil, Franz Josef
Madisch, Ahmed
Tappe, Ulrich
Schmidt, Harald
Terjung, Birgit
Klymiuk, Ingeborg
Horvath, Angela
Gross, Manfred
Stadlbauer, Vanessa
author_sort Labenz, Joachim
collection PubMed
description Even after decades of research and pharmaceutical development, cancer is still one of the most common causes of death in the western population and the management of cancer will remain a major challenge of medical research. One of the most common types of cancer is colorectal cancer (CRC). Prevention by detection of early-stage precursors is the most reliable method to prevent CRC development. In dependence of age, familial predisposition, and other risk factors the preventative routine screening for CRC by colonoscopy should be performed at least twice in intervals of about ten years. Although colonoscopy is a life-saving clinical examination reducing both incidence and mortality of CRC significantly, it has still a bad reputation in the population as an uncomfortable procedure with unpleasant side effects lasting sometimes over days to weeks. These effects are most likely caused by the bowel preparation before colonoscopy, which is crucial for a successful colonoscopy with high quality. Beside pain, bleeding and other rare but severe complications of colonoscopy, cleaning of the intestinal mucosa alters the gut microbiome significantly and consistently. Abdominal pain, cramps, diarrhea, nausea, bloating, and constipation are common adverse events which can continue to affect patients for days or even weeks after the procedure. In this multicenter, placebo controlled, double blind clinical trial, we investigated the effect of an intervention with a multispecies probiotic formulation for 30 days on the adverse events due to bowel preparation. We show that the treatment of participants with the multispecies probiotic formulation decreases the number of days with constipation significantly, and reduced pain, bloating, diarrhea, and general discomfort. 16S based amplicon analyses reveal recovery of administered probiotic strains from stool samples and differences in alpha diversity dynamics with higher variability in the probiotic group compared to the placebo group. In conclusion, the probiotic ameliorates the side effects after colonoscopy and might be an important supplement to increase acceptance of this life-saving preventative examination. Further, we present here for the first time that probiotic intervention of only 30 days affects alpha diversity parameters in stool samples.
format Online
Article
Text
id pubmed-9870247
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-98702472023-01-24 Application of a multispecies probiotic reduces gastro-intestinal discomfort and induces microbial changes after colonoscopy Labenz, Joachim Borkenstein, Daniela-Patricia Heil, Franz Josef Madisch, Ahmed Tappe, Ulrich Schmidt, Harald Terjung, Birgit Klymiuk, Ingeborg Horvath, Angela Gross, Manfred Stadlbauer, Vanessa Front Oncol Oncology Even after decades of research and pharmaceutical development, cancer is still one of the most common causes of death in the western population and the management of cancer will remain a major challenge of medical research. One of the most common types of cancer is colorectal cancer (CRC). Prevention by detection of early-stage precursors is the most reliable method to prevent CRC development. In dependence of age, familial predisposition, and other risk factors the preventative routine screening for CRC by colonoscopy should be performed at least twice in intervals of about ten years. Although colonoscopy is a life-saving clinical examination reducing both incidence and mortality of CRC significantly, it has still a bad reputation in the population as an uncomfortable procedure with unpleasant side effects lasting sometimes over days to weeks. These effects are most likely caused by the bowel preparation before colonoscopy, which is crucial for a successful colonoscopy with high quality. Beside pain, bleeding and other rare but severe complications of colonoscopy, cleaning of the intestinal mucosa alters the gut microbiome significantly and consistently. Abdominal pain, cramps, diarrhea, nausea, bloating, and constipation are common adverse events which can continue to affect patients for days or even weeks after the procedure. In this multicenter, placebo controlled, double blind clinical trial, we investigated the effect of an intervention with a multispecies probiotic formulation for 30 days on the adverse events due to bowel preparation. We show that the treatment of participants with the multispecies probiotic formulation decreases the number of days with constipation significantly, and reduced pain, bloating, diarrhea, and general discomfort. 16S based amplicon analyses reveal recovery of administered probiotic strains from stool samples and differences in alpha diversity dynamics with higher variability in the probiotic group compared to the placebo group. In conclusion, the probiotic ameliorates the side effects after colonoscopy and might be an important supplement to increase acceptance of this life-saving preventative examination. Further, we present here for the first time that probiotic intervention of only 30 days affects alpha diversity parameters in stool samples. Frontiers Media S.A. 2023-01-09 /pmc/articles/PMC9870247/ /pubmed/36698396 http://dx.doi.org/10.3389/fonc.2022.1078315 Text en Copyright © 2023 Labenz, Borkenstein, Heil, Madisch, Tappe, Schmidt, Terjung, Klymiuk, Horvath, Gross and Stadlbauer https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Labenz, Joachim
Borkenstein, Daniela-Patricia
Heil, Franz Josef
Madisch, Ahmed
Tappe, Ulrich
Schmidt, Harald
Terjung, Birgit
Klymiuk, Ingeborg
Horvath, Angela
Gross, Manfred
Stadlbauer, Vanessa
Application of a multispecies probiotic reduces gastro-intestinal discomfort and induces microbial changes after colonoscopy
title Application of a multispecies probiotic reduces gastro-intestinal discomfort and induces microbial changes after colonoscopy
title_full Application of a multispecies probiotic reduces gastro-intestinal discomfort and induces microbial changes after colonoscopy
title_fullStr Application of a multispecies probiotic reduces gastro-intestinal discomfort and induces microbial changes after colonoscopy
title_full_unstemmed Application of a multispecies probiotic reduces gastro-intestinal discomfort and induces microbial changes after colonoscopy
title_short Application of a multispecies probiotic reduces gastro-intestinal discomfort and induces microbial changes after colonoscopy
title_sort application of a multispecies probiotic reduces gastro-intestinal discomfort and induces microbial changes after colonoscopy
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9870247/
https://www.ncbi.nlm.nih.gov/pubmed/36698396
http://dx.doi.org/10.3389/fonc.2022.1078315
work_keys_str_mv AT labenzjoachim applicationofamultispeciesprobioticreducesgastrointestinaldiscomfortandinducesmicrobialchangesaftercolonoscopy
AT borkensteindanielapatricia applicationofamultispeciesprobioticreducesgastrointestinaldiscomfortandinducesmicrobialchangesaftercolonoscopy
AT heilfranzjosef applicationofamultispeciesprobioticreducesgastrointestinaldiscomfortandinducesmicrobialchangesaftercolonoscopy
AT madischahmed applicationofamultispeciesprobioticreducesgastrointestinaldiscomfortandinducesmicrobialchangesaftercolonoscopy
AT tappeulrich applicationofamultispeciesprobioticreducesgastrointestinaldiscomfortandinducesmicrobialchangesaftercolonoscopy
AT schmidtharald applicationofamultispeciesprobioticreducesgastrointestinaldiscomfortandinducesmicrobialchangesaftercolonoscopy
AT terjungbirgit applicationofamultispeciesprobioticreducesgastrointestinaldiscomfortandinducesmicrobialchangesaftercolonoscopy
AT klymiukingeborg applicationofamultispeciesprobioticreducesgastrointestinaldiscomfortandinducesmicrobialchangesaftercolonoscopy
AT horvathangela applicationofamultispeciesprobioticreducesgastrointestinaldiscomfortandinducesmicrobialchangesaftercolonoscopy
AT grossmanfred applicationofamultispeciesprobioticreducesgastrointestinaldiscomfortandinducesmicrobialchangesaftercolonoscopy
AT stadlbauervanessa applicationofamultispeciesprobioticreducesgastrointestinaldiscomfortandinducesmicrobialchangesaftercolonoscopy