Accuracy of the urine point-of-care circulating cathodic antigen assay for diagnosing Schistosomiasis mansoni infection in Brazil: A multicenter study

BACKGROUND: The World Health Organization recommends a market-ready, urine-based point-of-care diagnostic test for circulating cathodic antigens (CCA) to determine the prevalence of S. mansoni. This study evaluated the performance of the URINE CCA (SCHISTO) ECO TESTE® (POC-ECO), which is currently a...

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Detalles Bibliográficos
Autores principales: Pieri, Otavio Sarmento, Bezerra, Fernando Schemelzer Moraes, Coelho, Paulo Marcos Zech, Enk, Martin Johannes, Favre, Tereza Cristina, Graeff-Teixeira, Carlos, Oliveira, Ricardo Riccio, dos Reis, Mitermayer Galvão, Andrade, Lee Senhorinha de Almeida, Beck, Lilian Christina Nóbrega Holsbach, Favero, Vivian, Fialho, Thainá Rodrigues de Souza, Guimarães, Ricardo José de Paula Souza e, Oliveira, Bruna Souza Santos, Pascoal, Vanessa Fey, Pinheiro, Marta Cristhiany Cunha, dos Santos, Ronald Alves, Silva, Luciano Kalabric, de Siqueira, Isadora Cristina, de Souza, Renata Perotto, Katz, Naftale
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Medicina Tropical - SBMT 2023
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9870275/
https://www.ncbi.nlm.nih.gov/pubmed/36700600
http://dx.doi.org/10.1590/0037-8682-0238-2022
Descripción
Sumario:BACKGROUND: The World Health Organization recommends a market-ready, urine-based point-of-care diagnostic test for circulating cathodic antigens (CCA) to determine the prevalence of S. mansoni. This study evaluated the performance of the URINE CCA (SCHISTO) ECO TESTE® (POC-ECO), which is currently available in Brazil. METHODS: Residents from eight sites with different prevalence estimates provided one urine sample for POC-ECO and one stool sample for Kato-Katz (KK) and Helmintex® (HTX) testing as an egg-detecting reference for infection status. RESULTS: None of the study sites had significantly higher POC-ECO accuracy than KK. CONCLUSIONS: POC-ECO is not currently recommended in Brazilian schistosomiasis elimination programs.

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