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Tolerance and Adherence of Patients with Chronic Chagas Disease Treated with Benznidazole

BACKGROUND: Chagas disease (CD) treatment is commonly associated with a high incidence of adverse effects. It is crucial to study and update these adverse effects to improve the existing knowledge of which drugs to use and to clarify the information presented to patients. METHODS: We analyzed the ad...

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Autores principales: Vázquez, Cristina, García-Vázquez, Elisa, Carrilero, Bartolomé, Simón, Marina, Franco, Fuensanta, Iborra, María Asunción, Gil-Gallardo, Luis Javier, Segovia, Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Medicina Tropical - SBMT 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9870279/
https://www.ncbi.nlm.nih.gov/pubmed/36700605
http://dx.doi.org/10.1590/0037-8682-0384-2022
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author Vázquez, Cristina
García-Vázquez, Elisa
Carrilero, Bartolomé
Simón, Marina
Franco, Fuensanta
Iborra, María Asunción
Gil-Gallardo, Luis Javier
Segovia, Manuel
author_facet Vázquez, Cristina
García-Vázquez, Elisa
Carrilero, Bartolomé
Simón, Marina
Franco, Fuensanta
Iborra, María Asunción
Gil-Gallardo, Luis Javier
Segovia, Manuel
author_sort Vázquez, Cristina
collection PubMed
description BACKGROUND: Chagas disease (CD) treatment is commonly associated with a high incidence of adverse effects. It is crucial to study and update these adverse effects to improve the existing knowledge of which drugs to use and to clarify the information presented to patients. METHODS: We analyzed the adverse effects of benznidazole in two cohorts of patients: a large retrospective study and a small prospective study. RESULTS: This large retrospective study described the most and least common adverse effects in our area and characterized our Chagas disease population. This prospective study, along with a close follow-up of the treatment, detected more adverse effects and enhanced the patients’ perception of the disease and treatment. CONCLUSIONS: This information is important for preventing non-medical-related withdrawals and for removing baseless fears. Better knowledge of patients could help us provide better care.
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spelling pubmed-98702792023-02-01 Tolerance and Adherence of Patients with Chronic Chagas Disease Treated with Benznidazole Vázquez, Cristina García-Vázquez, Elisa Carrilero, Bartolomé Simón, Marina Franco, Fuensanta Iborra, María Asunción Gil-Gallardo, Luis Javier Segovia, Manuel Rev Soc Bras Med Trop Major Article BACKGROUND: Chagas disease (CD) treatment is commonly associated with a high incidence of adverse effects. It is crucial to study and update these adverse effects to improve the existing knowledge of which drugs to use and to clarify the information presented to patients. METHODS: We analyzed the adverse effects of benznidazole in two cohorts of patients: a large retrospective study and a small prospective study. RESULTS: This large retrospective study described the most and least common adverse effects in our area and characterized our Chagas disease population. This prospective study, along with a close follow-up of the treatment, detected more adverse effects and enhanced the patients’ perception of the disease and treatment. CONCLUSIONS: This information is important for preventing non-medical-related withdrawals and for removing baseless fears. Better knowledge of patients could help us provide better care. Sociedade Brasileira de Medicina Tropical - SBMT 2023-01-23 /pmc/articles/PMC9870279/ /pubmed/36700605 http://dx.doi.org/10.1590/0037-8682-0384-2022 Text en https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License
spellingShingle Major Article
Vázquez, Cristina
García-Vázquez, Elisa
Carrilero, Bartolomé
Simón, Marina
Franco, Fuensanta
Iborra, María Asunción
Gil-Gallardo, Luis Javier
Segovia, Manuel
Tolerance and Adherence of Patients with Chronic Chagas Disease Treated with Benznidazole
title Tolerance and Adherence of Patients with Chronic Chagas Disease Treated with Benznidazole
title_full Tolerance and Adherence of Patients with Chronic Chagas Disease Treated with Benznidazole
title_fullStr Tolerance and Adherence of Patients with Chronic Chagas Disease Treated with Benznidazole
title_full_unstemmed Tolerance and Adherence of Patients with Chronic Chagas Disease Treated with Benznidazole
title_short Tolerance and Adherence of Patients with Chronic Chagas Disease Treated with Benznidazole
title_sort tolerance and adherence of patients with chronic chagas disease treated with benznidazole
topic Major Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9870279/
https://www.ncbi.nlm.nih.gov/pubmed/36700605
http://dx.doi.org/10.1590/0037-8682-0384-2022
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