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Tolerance and Adherence of Patients with Chronic Chagas Disease Treated with Benznidazole
BACKGROUND: Chagas disease (CD) treatment is commonly associated with a high incidence of adverse effects. It is crucial to study and update these adverse effects to improve the existing knowledge of which drugs to use and to clarify the information presented to patients. METHODS: We analyzed the ad...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade Brasileira de Medicina Tropical - SBMT
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9870279/ https://www.ncbi.nlm.nih.gov/pubmed/36700605 http://dx.doi.org/10.1590/0037-8682-0384-2022 |
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author | Vázquez, Cristina García-Vázquez, Elisa Carrilero, Bartolomé Simón, Marina Franco, Fuensanta Iborra, María Asunción Gil-Gallardo, Luis Javier Segovia, Manuel |
author_facet | Vázquez, Cristina García-Vázquez, Elisa Carrilero, Bartolomé Simón, Marina Franco, Fuensanta Iborra, María Asunción Gil-Gallardo, Luis Javier Segovia, Manuel |
author_sort | Vázquez, Cristina |
collection | PubMed |
description | BACKGROUND: Chagas disease (CD) treatment is commonly associated with a high incidence of adverse effects. It is crucial to study and update these adverse effects to improve the existing knowledge of which drugs to use and to clarify the information presented to patients. METHODS: We analyzed the adverse effects of benznidazole in two cohorts of patients: a large retrospective study and a small prospective study. RESULTS: This large retrospective study described the most and least common adverse effects in our area and characterized our Chagas disease population. This prospective study, along with a close follow-up of the treatment, detected more adverse effects and enhanced the patients’ perception of the disease and treatment. CONCLUSIONS: This information is important for preventing non-medical-related withdrawals and for removing baseless fears. Better knowledge of patients could help us provide better care. |
format | Online Article Text |
id | pubmed-9870279 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Sociedade Brasileira de Medicina Tropical - SBMT |
record_format | MEDLINE/PubMed |
spelling | pubmed-98702792023-02-01 Tolerance and Adherence of Patients with Chronic Chagas Disease Treated with Benznidazole Vázquez, Cristina García-Vázquez, Elisa Carrilero, Bartolomé Simón, Marina Franco, Fuensanta Iborra, María Asunción Gil-Gallardo, Luis Javier Segovia, Manuel Rev Soc Bras Med Trop Major Article BACKGROUND: Chagas disease (CD) treatment is commonly associated with a high incidence of adverse effects. It is crucial to study and update these adverse effects to improve the existing knowledge of which drugs to use and to clarify the information presented to patients. METHODS: We analyzed the adverse effects of benznidazole in two cohorts of patients: a large retrospective study and a small prospective study. RESULTS: This large retrospective study described the most and least common adverse effects in our area and characterized our Chagas disease population. This prospective study, along with a close follow-up of the treatment, detected more adverse effects and enhanced the patients’ perception of the disease and treatment. CONCLUSIONS: This information is important for preventing non-medical-related withdrawals and for removing baseless fears. Better knowledge of patients could help us provide better care. Sociedade Brasileira de Medicina Tropical - SBMT 2023-01-23 /pmc/articles/PMC9870279/ /pubmed/36700605 http://dx.doi.org/10.1590/0037-8682-0384-2022 Text en https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License |
spellingShingle | Major Article Vázquez, Cristina García-Vázquez, Elisa Carrilero, Bartolomé Simón, Marina Franco, Fuensanta Iborra, María Asunción Gil-Gallardo, Luis Javier Segovia, Manuel Tolerance and Adherence of Patients with Chronic Chagas Disease Treated with Benznidazole |
title | Tolerance and Adherence of Patients with Chronic Chagas Disease Treated with Benznidazole |
title_full | Tolerance and Adherence of Patients with Chronic Chagas Disease Treated with Benznidazole |
title_fullStr | Tolerance and Adherence of Patients with Chronic Chagas Disease Treated with Benznidazole |
title_full_unstemmed | Tolerance and Adherence of Patients with Chronic Chagas Disease Treated with Benznidazole |
title_short | Tolerance and Adherence of Patients with Chronic Chagas Disease Treated with Benznidazole |
title_sort | tolerance and adherence of patients with chronic chagas disease treated with benznidazole |
topic | Major Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9870279/ https://www.ncbi.nlm.nih.gov/pubmed/36700605 http://dx.doi.org/10.1590/0037-8682-0384-2022 |
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