Genomic and transcriptomic analysis of MSI-H colorectal cancer patients with targetable alterations identifies clinical implications for immunotherapy

INTRODUCTION: Targetable alterations such as BRAFV600E mutation and NTRK fusion are enriched in microsatellite instability-high (MSI-H) colorectal cancer (CRC). MSI-H with targetable alterations (MSI-H altered) might present unique opportunities for both targeted therapy and immunotherapy. We system...

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Detalles Bibliográficos
Autores principales: Hua, Hanju, He, Wenguang, Chen, Nan, He, Yinjun, Wu, Guosheng, Ye, Feng, Zhou, Xile, Li, Yandong, Ding, Yongfeng, Zhong, Weixiang, Teng, Lisong, Jiang, Weiqin, Sheng, Qinsong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9870311/
https://www.ncbi.nlm.nih.gov/pubmed/36700211
http://dx.doi.org/10.3389/fimmu.2022.974793

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