The role of Th17 cells in inflammatory bowel disease and the research progress

Th17 cells play an important role in the abnormal immune response in inflammatory bowel disease (IBD) and are involved in the development and progression of inflammation and fibrosis. An increasing amount of data has shown that gut microbes are important parts of intestinal immunity and regulators o...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Lu, Ruan, Guangcong, Cheng, Yi, Yi, Ailin, Chen, Dongfeng, Wei, Yanling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9870314/
https://www.ncbi.nlm.nih.gov/pubmed/36700221
http://dx.doi.org/10.3389/fimmu.2022.1055914
_version_ 1784876950013083648
author Chen, Lu
Ruan, Guangcong
Cheng, Yi
Yi, Ailin
Chen, Dongfeng
Wei, Yanling
author_facet Chen, Lu
Ruan, Guangcong
Cheng, Yi
Yi, Ailin
Chen, Dongfeng
Wei, Yanling
author_sort Chen, Lu
collection PubMed
description Th17 cells play an important role in the abnormal immune response in inflammatory bowel disease (IBD) and are involved in the development and progression of inflammation and fibrosis. An increasing amount of data has shown that gut microbes are important parts of intestinal immunity and regulators of Th17 cellular immunity. Th17 cell differentiation is regulated by intestinal bacteria and cytokines, and Th17 cells regulate the intestinal mucosal immune microenvironment by secreting cytokines, such as IL-17, IL-21, and IL-26. Solid evidence showed that, regarding the treatment of IBD by targeting Th17 cells, the therapeutic effect of different biological agents varies greatly. Fecal bacteria transplantation (FMT) in the treatment of IBD has been a popular research topic in recent years and is safe and effective with few side effects. To further understand the role of Th17 cells in the progression of IBD and associated therapeutic prospects, this review will discuss the progress of related research on Th17 cells in IBD by focusing on the interaction and immune regulation between Th17 cells and gut microbiota.
format Online
Article
Text
id pubmed-9870314
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-98703142023-01-24 The role of Th17 cells in inflammatory bowel disease and the research progress Chen, Lu Ruan, Guangcong Cheng, Yi Yi, Ailin Chen, Dongfeng Wei, Yanling Front Immunol Immunology Th17 cells play an important role in the abnormal immune response in inflammatory bowel disease (IBD) and are involved in the development and progression of inflammation and fibrosis. An increasing amount of data has shown that gut microbes are important parts of intestinal immunity and regulators of Th17 cellular immunity. Th17 cell differentiation is regulated by intestinal bacteria and cytokines, and Th17 cells regulate the intestinal mucosal immune microenvironment by secreting cytokines, such as IL-17, IL-21, and IL-26. Solid evidence showed that, regarding the treatment of IBD by targeting Th17 cells, the therapeutic effect of different biological agents varies greatly. Fecal bacteria transplantation (FMT) in the treatment of IBD has been a popular research topic in recent years and is safe and effective with few side effects. To further understand the role of Th17 cells in the progression of IBD and associated therapeutic prospects, this review will discuss the progress of related research on Th17 cells in IBD by focusing on the interaction and immune regulation between Th17 cells and gut microbiota. Frontiers Media S.A. 2023-01-09 /pmc/articles/PMC9870314/ /pubmed/36700221 http://dx.doi.org/10.3389/fimmu.2022.1055914 Text en Copyright © 2023 Chen, Ruan, Cheng, Yi, Chen and Wei https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Chen, Lu
Ruan, Guangcong
Cheng, Yi
Yi, Ailin
Chen, Dongfeng
Wei, Yanling
The role of Th17 cells in inflammatory bowel disease and the research progress
title The role of Th17 cells in inflammatory bowel disease and the research progress
title_full The role of Th17 cells in inflammatory bowel disease and the research progress
title_fullStr The role of Th17 cells in inflammatory bowel disease and the research progress
title_full_unstemmed The role of Th17 cells in inflammatory bowel disease and the research progress
title_short The role of Th17 cells in inflammatory bowel disease and the research progress
title_sort role of th17 cells in inflammatory bowel disease and the research progress
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9870314/
https://www.ncbi.nlm.nih.gov/pubmed/36700221
http://dx.doi.org/10.3389/fimmu.2022.1055914
work_keys_str_mv AT chenlu theroleofth17cellsininflammatoryboweldiseaseandtheresearchprogress
AT ruanguangcong theroleofth17cellsininflammatoryboweldiseaseandtheresearchprogress
AT chengyi theroleofth17cellsininflammatoryboweldiseaseandtheresearchprogress
AT yiailin theroleofth17cellsininflammatoryboweldiseaseandtheresearchprogress
AT chendongfeng theroleofth17cellsininflammatoryboweldiseaseandtheresearchprogress
AT weiyanling theroleofth17cellsininflammatoryboweldiseaseandtheresearchprogress
AT chenlu roleofth17cellsininflammatoryboweldiseaseandtheresearchprogress
AT ruanguangcong roleofth17cellsininflammatoryboweldiseaseandtheresearchprogress
AT chengyi roleofth17cellsininflammatoryboweldiseaseandtheresearchprogress
AT yiailin roleofth17cellsininflammatoryboweldiseaseandtheresearchprogress
AT chendongfeng roleofth17cellsininflammatoryboweldiseaseandtheresearchprogress
AT weiyanling roleofth17cellsininflammatoryboweldiseaseandtheresearchprogress

Ejemplares similares