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Case report: Ketogenic diet acutely improves cognitive function in patient with Down syndrome and Alzheimer’s disease

Ketogenic diets have a century-long history as a therapeutic tool to treat intractable epilepsy. Recently, a renewed interest in neuroketotherapeutics has arisen, with ketogenic diets being explored for the treatment of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease,...

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Autores principales: Bosworth, Annette, Loh, Vyvyane, Stranahan, Blackjack N., Palmer, Christopher M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9870323/
https://www.ncbi.nlm.nih.gov/pubmed/36699496
http://dx.doi.org/10.3389/fpsyt.2022.1085512
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author Bosworth, Annette
Loh, Vyvyane
Stranahan, Blackjack N.
Palmer, Christopher M.
author_facet Bosworth, Annette
Loh, Vyvyane
Stranahan, Blackjack N.
Palmer, Christopher M.
author_sort Bosworth, Annette
collection PubMed
description Ketogenic diets have a century-long history as a therapeutic tool to treat intractable epilepsy. Recently, a renewed interest in neuroketotherapeutics has arisen, with ketogenic diets being explored for the treatment of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease, as well as mental health conditions. Herein, we present a case report of a 47-year-old woman with Down syndrome diagnosed with Alzheimer’s disease and absence seizures with accelerated cognitive decline over 6 years. A ketogenic diet restored her cognitive function over 6 weeks, with an increase in Activities of Daily Living Scale score from 34 to 58. A therapeutic ketogenic diet was associated with significant cognitive improvement in this patient with concurrent Down syndrome and dementia.
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spelling pubmed-98703232023-01-24 Case report: Ketogenic diet acutely improves cognitive function in patient with Down syndrome and Alzheimer’s disease Bosworth, Annette Loh, Vyvyane Stranahan, Blackjack N. Palmer, Christopher M. Front Psychiatry Psychiatry Ketogenic diets have a century-long history as a therapeutic tool to treat intractable epilepsy. Recently, a renewed interest in neuroketotherapeutics has arisen, with ketogenic diets being explored for the treatment of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease, as well as mental health conditions. Herein, we present a case report of a 47-year-old woman with Down syndrome diagnosed with Alzheimer’s disease and absence seizures with accelerated cognitive decline over 6 years. A ketogenic diet restored her cognitive function over 6 weeks, with an increase in Activities of Daily Living Scale score from 34 to 58. A therapeutic ketogenic diet was associated with significant cognitive improvement in this patient with concurrent Down syndrome and dementia. Frontiers Media S.A. 2023-01-09 /pmc/articles/PMC9870323/ /pubmed/36699496 http://dx.doi.org/10.3389/fpsyt.2022.1085512 Text en Copyright © 2023 Bosworth, Loh, Stranahan and Palmer. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Bosworth, Annette
Loh, Vyvyane
Stranahan, Blackjack N.
Palmer, Christopher M.
Case report: Ketogenic diet acutely improves cognitive function in patient with Down syndrome and Alzheimer’s disease
title Case report: Ketogenic diet acutely improves cognitive function in patient with Down syndrome and Alzheimer’s disease
title_full Case report: Ketogenic diet acutely improves cognitive function in patient with Down syndrome and Alzheimer’s disease
title_fullStr Case report: Ketogenic diet acutely improves cognitive function in patient with Down syndrome and Alzheimer’s disease
title_full_unstemmed Case report: Ketogenic diet acutely improves cognitive function in patient with Down syndrome and Alzheimer’s disease
title_short Case report: Ketogenic diet acutely improves cognitive function in patient with Down syndrome and Alzheimer’s disease
title_sort case report: ketogenic diet acutely improves cognitive function in patient with down syndrome and alzheimer’s disease
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9870323/
https://www.ncbi.nlm.nih.gov/pubmed/36699496
http://dx.doi.org/10.3389/fpsyt.2022.1085512
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