Cargando…

Evaluation of the Combination of Metformin and Rapamycin in an MPP(+)-Treated SH-SY5Y Model of Parkinson's Disease

Metformin (MET) and rapamycin (RAPA) have been reported to protect against neurodegeneration in cellular and animal models of Parkinson's disease (PD). MET, which is a first-line drug for type 2 diabetes, and RAPA are known as mTORC1 inhibitors. MET also acts as an AMPK activator, which leads t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Norradee, Chureerat, Khwanraj, Kawinthra, Balit, Tatcha, Dharmasaroja, Permphan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9870674/ https://www.ncbi.nlm.nih.gov/pubmed/36698448 http://dx.doi.org/10.1155/2023/3830861

Ejemplares similares

Differential Expression of Tyrosine Hydroxylase Protein and Apoptosis-Related Genes in Differentiated and Undifferentiated SH-SY5Y Neuroblastoma Cells Treated with MPP(+)
por: Khwanraj, Kawinthra, et al.
Publicado: (2015)

eEF1A2 siRNA Suppresses MPP(+)-Induced Activation of Akt and mTOR and Potentiates Caspase-3 Activation in a Parkinson's Disease Model
por: Khwanraj, Kawinthra, et al.
Publicado: (2023)

Metformin restores the mitochondrial membrane potentials in association with a reduction in TIMM23 and NDUFS3 in MPP+-induced neurotoxicity in SH-SY5Y cells
por: Chanthammachat, Pitak, et al.
Publicado: (2019)

Neuroprotective Effects of Alpha-Mangostin on MPP(+)-Induced Apoptotic Cell Death in Neuroblastoma SH-SY5Y Cells
por: Janhom, Prachya, et al.
Publicado: (2015)

Neuroblastoma Cell Death Induced by eEF1A2 Knockdown Is Possibly Mediated by the Inhibition of Akt and mTOR Phosphorylation
por: Khwanraj, Kawinthra, et al.
Publicado: (2021)

Comparative mRNA Expression of eEF1A Isoforms and a PI3K/Akt/mTOR Pathway in a Cellular Model of Parkinson's Disease
por: Khwanraj, Kawinthra, et al.
Publicado: (2016)

Aberrant proteins expressed in skin fibroblasts of Parkinson's disease patients carrying heterozygous variants of glucocerebrosidase and parkin genes
por: Sawangareetrakul, Phannee, et al.
Publicado: (2021)

Artemisinin attenuated oxidative stress and apoptosis by inhibiting autophagy in MPP(+)-treated SH-SY5Y cells
por: Yan, Junqiang, et al.
Publicado: (2021)

Mitochondrial Effects of PGC-1alpha Silencing in MPP(+) Treated Human SH-SY5Y Neuroblastoma Cells
por: Ye, Qinyong, et al.
Publicado: (2017)

The S-nitrosylation of parkin attenuated the ubiquitination of divalent metal transporter 1 in MPP(+)-treated SH-SY5Y cells
por: Zhong, Yanmin, et al.
Publicado: (2020)

Sophora flavescens Aiton Decreases MPP(+)-Induced Mitochondrial Dysfunction in SH-SY5Y Cells
por: Kim, Hee-Young, et al.
Publicado: (2018)

Metabolomic analysis data of MPP(+)-exposed SH-SY5Y cells using CE-TOFMS
por: Amo, Taku, et al.
Publicado: (2020)

MPP+ induces necrostatin-1- and ferrostatin-1-sensitive necrotic death of neuronal SH-SY5Y cells
por: Ito, Keisuke, et al.
Publicado: (2017)

The Degradation of TMEM166 by Autophagy Promotes AMPK Activation to Protect SH-SY5Y Cells Exposed to MPP(+)
por: Liao, Zhaozhong, et al.
Publicado: (2022)

Carnitine Protects against MPP(+)-Induced Neurotoxicity and Inflammation by Promoting Primary Ciliogenesis in SH-SY5Y Cells
por: Bae, Ji-Eun, et al.
Publicado: (2022)

MiR-212 Attenuates MPP(+)-Induced Neuronal Damage by Targeting KLF4 in SH-SY5Y Cells
por: Song, Yanfeng, et al.
Publicado: (2018)

MTERF3 contributes to MPP+-induced mitochondrial dysfunction in SH-SY5Y cells: MTERF3 in mitochondrial dysfunction
por: Zhu, Shun, et al.
Publicado: (2022)

Salsolinol Protects SH-SY5Y Cells Against MPP(+) Damage and Increases Enteric S100-Immunoreactivity in Wistar Rats
por: Kurnik-Łucka, Magdalena, et al.
Publicado: (2022)

Stroke Outcomes in Thai Elderly Patients Treated with and without Intravenous Thrombolysis
por: A. Dharmasaroja, Pornpatr, et al.
Publicado: (2013)

The Impairments of α-Synuclein and Mechanistic Target of Rapamycin in Rotenone-Induced SH-SY5Y Cells and Mice Model of Parkinson’s Disease
por: Ramalingam, Mahesh, et al.
Publicado: (2019)

LincRNA-p21 Promotes Cellular Senescence by Down-regulating the Wnt/β-catenin Pathway in MPP(+)-treated SH-SY5Y Cells
por: Zhu, Jianyu, et al.
Publicado: (2023)

Damage of Neuroblastoma Cell SH-SY5Y Mediated by MPP(+) Inhibits Proliferation of T-Cell Leukemia Jurkat by Co-Culture System
por: Wang, Fuli, et al.
Publicado: (2014)

Delta-9-tetrahydrocannabinol protects against MPP(+) toxicity in SH-SY5Y cells by restoring proteins involved in mitochondrial biogenesis
por: Zeissler, Marie-Louise, et al.
Publicado: (2016)

miR‐34a/BCL‐2 signaling axis contributes to apoptosis in MPP(+)‐induced SH‐SY5Y cells
por: Shanesazzade, Zahra, et al.
Publicado: (2018)

Correction to: Salsolinol Protects SH-SY5Y Cells Against MPP(+) Damage and Increases Enteric S100‐Immunoreactivity in Wistar Rats
por: Kurnik-Łucka, Magdalena, et al.
Publicado: (2023)

Rapamycin reverses ferroptosis by increasing autophagy in MPTP/MPP(+)-induced models of Parkinson’s disease
por: Liu, Tongyu, et al.
Publicado: (2023)

Early Flare-Ups of Myasthenia Gravis After Thoracoscopic Thymectomy in a Patient Recently Receiving BNT162b2 mRNA COVID-19 Vaccination
por: Dharmasaroja, Permphan
Publicado: (2022)

Episodic Headache, Periorbital Pain, and Multifocal Paresthesias as Presenting Symptoms of Central Neurocytoma: A Case Report
por: Dharmasaroja, Permphan
Publicado: (2023)

Protective effects of Cervus nippon Temminck velvet antler polypeptides against MPP(+)-induced cytotoxicity in SH-SY5Y neuroblastoma cells
por: Xin, Ji-Le, et al.
Publicado: (2017)

β-Naphtoflavone and Ethanol Induce Cytochrome P450 and Protect towards MPP(+) Toxicity in Human Neuroblastoma SH-SY5Y Cells
por: Fernandez-Abascal, Jesus, et al.
Publicado: (2018)

Protective Effect of Fucoidan against MPP(+)-Induced SH-SY5Y Cells Apoptosis by Affecting the PI3K/Akt Pathway
por: Liu, Huaide, et al.
Publicado: (2020)

Retraction: Knockdown of NEAT1 ameliorated MPP(+)-induced neuronal damage by sponging miR-221 in SH-SY5Y cells
por: Fisher, Laura
Publicado: (2021)

Neuroprotection of Andrographolide against Neurotoxin MPP(+)-Induced Apoptosis in SH-SY5Y Cells via Activating Mitophagy, Autophagy, and Antioxidant Activities
por: Prasertsuksri, Prachayaporn, et al.
Publicado: (2023)

Lipid Analysis of the 6-Hydroxydopamine-Treated SH-SY5Y Cell Model for Parkinson’s Disease
por: Xicoy, Helena, et al.
Publicado: (2019)

Altered expression of miR-29a-3p and miR-34a-5p by specific inhibition of GSK3β in the MPP(+) treated SH-SY5Y Parkinson's model
por: Ahmadzadeh-Darinsoo, Morteza, et al.
Publicado: (2022)

Young Coconut Juice Reduces Some Histopathological Changes Associated with Alzheimer's Disease through the Modulation of Estrogen Receptors in Orchidectomized Rat Brains
por: Balit, Tatcha, et al.
Publicado: (2019)

Cx43 Mediates Resistance against MPP(+)-Induced Apoptosis in SH-SY5Y Neuroblastoma Cells via Modulating the Mitochondrial Apoptosis Pathway
por: Kim, In-Su, et al.
Publicado: (2016)

miR-135b Plays a Neuroprotective Role by Targeting GSK3β in MPP(+)-Intoxicated SH-SY5Y Cells
por: Zhang, Jianlei, et al.
Publicado: (2017)

Retraction: LncRNA MALAT1 aggravates MPP-induced neuronal injury by regulating miR-212 in SH-SY5Y cells
por: Fisher, Laura
Publicado: (2021)

Retracted Article: Knockdown of NEAT1 ameliorated MPP(+)-induced neuronal damage by sponging miR-221 in SH-SY5Y cells
por: Geng, Lijiao, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_9h26a41gveghj6jgmkbtkc0831