Optimization of the proliferation and persistency of CAR T cells derived from human induced pluripotent stem cells

The effectiveness of chimaeric antigen receptor (CAR) T-cell immunotherapies against solid tumours relies on the accumulation, proliferation and persistency of T cells at the tumour site. Here we show that the proliferation of CD8αβ cytotoxic CAR T cells in solid tumours can be enhanced by deriving...

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Detalles Bibliográficos
Autores principales: Ueda, Tatsuki, Shiina, Sara, Iriguchi, Shoichi, Terakura, Seitaro, Kawai, Yohei, Kabai, Ryotaro, Sakamoto, Satoko, Watanabe, Akira, Ohara, Kohei, Wang, Bo, Xu, Huaigeng, Minagawa, Atsutaka, Hotta, Akitsu, Woltjen, Knut, Uemura, Yasushi, Kodama, Yuzo, Seno, Hiroshi, Nakatsura, Tetsuya, Tamada, Koji, Kaneko, Shin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9870784/
https://www.ncbi.nlm.nih.gov/pubmed/36509913
http://dx.doi.org/10.1038/s41551-022-00969-0

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