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“Vascular inflammation and cardiovascular disease: review about the role of PET imaging”
Inflammation characterizes all stages of atherothrombosis and provides a critical pathophysiological link between plaque formation and its acute rupture, leading to coronary occlusion and heart attack. In the last 20 years the possibility of quantifying the degree of inflammation of atherosclerotic...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Netherlands
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9870832/ https://www.ncbi.nlm.nih.gov/pubmed/36255543 http://dx.doi.org/10.1007/s10554-022-02730-9 |
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author | Sammartino, Antonio Maria Falco, Raffaele Drera, Andrea Dondi, Francesco Bellini, Pietro Bertagna, Francesco Vizzardi, Enrico |
author_facet | Sammartino, Antonio Maria Falco, Raffaele Drera, Andrea Dondi, Francesco Bellini, Pietro Bertagna, Francesco Vizzardi, Enrico |
author_sort | Sammartino, Antonio Maria |
collection | PubMed |
description | Inflammation characterizes all stages of atherothrombosis and provides a critical pathophysiological link between plaque formation and its acute rupture, leading to coronary occlusion and heart attack. In the last 20 years the possibility of quantifying the degree of inflammation of atherosclerotic plaques and, therefore, also of vascular inflammation aroused much interest. (18)Fluoro-deoxy-glucose photon-emissions-tomography ((18)F-FDG-PET) is widely used in oncology for staging and searching metastases; in cardiology, the absorption of (18)F-FDG into the arterial wall was observed for the first time incidentally in the aorta of patients undergoing PET imaging for cancer staging. PET/CT imaging with (18)F-FDG and (18)F-sodium fluoride ((18)F-NaF) has been shown to assess atherosclerotic disease in its molecular phase, when the process may still be reversible. This approach has several limitations in the clinical practice, due to lack of prospective data to justify their use routinely, but it’s desirable to develop further scientific evidence to confirm this technique to detect high-risk patients for cardiovascular events. |
format | Online Article Text |
id | pubmed-9870832 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer Netherlands |
record_format | MEDLINE/PubMed |
spelling | pubmed-98708322023-01-25 “Vascular inflammation and cardiovascular disease: review about the role of PET imaging” Sammartino, Antonio Maria Falco, Raffaele Drera, Andrea Dondi, Francesco Bellini, Pietro Bertagna, Francesco Vizzardi, Enrico Int J Cardiovasc Imaging Review Inflammation characterizes all stages of atherothrombosis and provides a critical pathophysiological link between plaque formation and its acute rupture, leading to coronary occlusion and heart attack. In the last 20 years the possibility of quantifying the degree of inflammation of atherosclerotic plaques and, therefore, also of vascular inflammation aroused much interest. (18)Fluoro-deoxy-glucose photon-emissions-tomography ((18)F-FDG-PET) is widely used in oncology for staging and searching metastases; in cardiology, the absorption of (18)F-FDG into the arterial wall was observed for the first time incidentally in the aorta of patients undergoing PET imaging for cancer staging. PET/CT imaging with (18)F-FDG and (18)F-sodium fluoride ((18)F-NaF) has been shown to assess atherosclerotic disease in its molecular phase, when the process may still be reversible. This approach has several limitations in the clinical practice, due to lack of prospective data to justify their use routinely, but it’s desirable to develop further scientific evidence to confirm this technique to detect high-risk patients for cardiovascular events. Springer Netherlands 2022-10-18 2023 /pmc/articles/PMC9870832/ /pubmed/36255543 http://dx.doi.org/10.1007/s10554-022-02730-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Sammartino, Antonio Maria Falco, Raffaele Drera, Andrea Dondi, Francesco Bellini, Pietro Bertagna, Francesco Vizzardi, Enrico “Vascular inflammation and cardiovascular disease: review about the role of PET imaging” |
title | “Vascular inflammation and cardiovascular disease: review about the role of PET imaging” |
title_full | “Vascular inflammation and cardiovascular disease: review about the role of PET imaging” |
title_fullStr | “Vascular inflammation and cardiovascular disease: review about the role of PET imaging” |
title_full_unstemmed | “Vascular inflammation and cardiovascular disease: review about the role of PET imaging” |
title_short | “Vascular inflammation and cardiovascular disease: review about the role of PET imaging” |
title_sort | “vascular inflammation and cardiovascular disease: review about the role of pet imaging” |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9870832/ https://www.ncbi.nlm.nih.gov/pubmed/36255543 http://dx.doi.org/10.1007/s10554-022-02730-9 |
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