Structural and dynamic insights into supra-physiological activation and allosteric modulation of a muscarinic acetylcholine receptor

The M2 muscarinic receptor (M2R) is a prototypical G-protein-coupled receptor (GPCR) that serves as a model system for understanding GPCR regulation by both orthosteric and allosteric ligands. Here, we investigate the mechanisms governing M2R signaling versatility using cryo-electron microscopy (cry...

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Detalles Bibliográficos
Autores principales: Xu, Jun, Wang, Qinggong, Hübner, Harald, Hu, Yunfei, Niu, Xiaogang, Wang, Haoqing, Maeda, Shoji, Inoue, Asuka, Tao, Yuyong, Gmeiner, Peter, Du, Yang, Jin, Changwen, Kobilka, Brian K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9870890/
https://www.ncbi.nlm.nih.gov/pubmed/36690613
http://dx.doi.org/10.1038/s41467-022-35726-z

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