Building train carriages for ciliary transport: (IFT-)A complex task

Cilia assembly and function require intraflagellar transport (IFT), a mechanism that uses “trains” to transport cargoes into and out of cilia. While much has been learned about IFT in the past decades, IFT train assembly, loading of cargo and transport regulation have remained poorly understood. In...

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Detalles Bibliográficos
Autores principales: Gonçalves-Santos, Francisco, De-Castro, Maria J. G., De-Castro, Ana R. G., Dantas, Tiago J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Research Highlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9870902/
https://www.ncbi.nlm.nih.gov/pubmed/36690675
http://dx.doi.org/10.1038/s42003-023-04426-9
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author Gonçalves-Santos, Francisco
De-Castro, Maria J. G.
De-Castro, Ana R. G.
Dantas, Tiago J.
author_facet Gonçalves-Santos, Francisco
De-Castro, Maria J. G.
De-Castro, Ana R. G.
Dantas, Tiago J.
author_sort Gonçalves-Santos, Francisco
collection PubMed
description Cilia assembly and function require intraflagellar transport (IFT), a mechanism that uses “trains” to transport cargoes into and out of cilia. While much has been learned about IFT in the past decades, IFT train assembly, loading of cargo and transport regulation have remained poorly understood. In a recent study, Hesketh, Mukhopadhyay and colleagues obtained the complete structure of the IFT-A complex, a key element of IFT trains. By modelling IFT-A into anterograde trains and performing structure-guided mutagenesis, the authors uncover how the IFT-A complex polymerizes and forms carriages to accomplish its distinctive functions.
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spelling pubmed-98709022023-01-25 Building train carriages for ciliary transport: (IFT-)A complex task Gonçalves-Santos, Francisco De-Castro, Maria J. G. De-Castro, Ana R. G. Dantas, Tiago J. Commun Biol Research Highlight Cilia assembly and function require intraflagellar transport (IFT), a mechanism that uses “trains” to transport cargoes into and out of cilia. While much has been learned about IFT in the past decades, IFT train assembly, loading of cargo and transport regulation have remained poorly understood. In a recent study, Hesketh, Mukhopadhyay and colleagues obtained the complete structure of the IFT-A complex, a key element of IFT trains. By modelling IFT-A into anterograde trains and performing structure-guided mutagenesis, the authors uncover how the IFT-A complex polymerizes and forms carriages to accomplish its distinctive functions. Nature Publishing Group UK 2023-01-23 /pmc/articles/PMC9870902/ /pubmed/36690675 http://dx.doi.org/10.1038/s42003-023-04426-9 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research Highlight
Gonçalves-Santos, Francisco
De-Castro, Maria J. G.
De-Castro, Ana R. G.
Dantas, Tiago J.
Building train carriages for ciliary transport: (IFT-)A complex task
title Building train carriages for ciliary transport: (IFT-)A complex task
title_full Building train carriages for ciliary transport: (IFT-)A complex task
title_fullStr Building train carriages for ciliary transport: (IFT-)A complex task
title_full_unstemmed Building train carriages for ciliary transport: (IFT-)A complex task
title_short Building train carriages for ciliary transport: (IFT-)A complex task
title_sort building train carriages for ciliary transport: (ift-)a complex task
topic Research Highlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9870902/
https://www.ncbi.nlm.nih.gov/pubmed/36690675
http://dx.doi.org/10.1038/s42003-023-04426-9
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