Structural mechanism of BRD4-NUT and p300 bipartite interaction in propagating aberrant gene transcription in chromatin in NUT carcinoma

BRD4-NUT, a driver fusion mutant in rare and highly aggressive NUT carcinoma, acts in aberrant transcription of anti-differentiation genes by recruiting histone acetyltransferase (HAT) p300 and promoting p300-driven histone hyperacetylation and nuclear condensation in chromatin. However, the molecul...

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Detalles Bibliográficos
Autores principales: Yu, Di, Liang, Yingying, Kim, Claudia, Jaganathan, Anbalagan, Ji, Donglei, Han, Xinye, Yang, Xuelan, Jia, Yanjie, Gu, Ruirui, Wang, Chunyu, Zhang, Qiang, Cheung, Ka Lung, Zhou, Ming-Ming, Zeng, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9870903/
https://www.ncbi.nlm.nih.gov/pubmed/36690674
http://dx.doi.org/10.1038/s41467-023-36063-5

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